阿尔采木病经颅多普勒检查的研究  

A study of transcranial doppler in patients with Alzheimer'disease.

作　　者：吴瑞技 何晓峡[1] 叶勤[1] 

机构地区：[1]南京医科大学脑科医院

出　　处：《临床精神医学杂志》1995年第5期267-269,共3页Journal of Clinical Psychiatry

摘　　要：应用经颅多普勒（ＴＣＤ）检查２８例阿尔采木病（ＡＤ）和３０例多发梗塞性痴呆（ＭＩＤ），发现脑血液流速均显著低于同龄正常对照组（Ｐ＜０．０５）．此两患者组无明显差异（Ｐ＞０．０５），ＡＤ组ＴＣＤ异常率为７８．６％，其中颅内段血管狭窄为２８．６％，颅外段血管狭窄为４２．９％，左侧大脑中动脉闭塞为７．１％，提示两患者组的脑动脉病理改变基本相仿。对临床有关因素及治疗等进行了讨论。AbstractObjective:To study the changes of cerebral blood stream in Alzheimer'disease(AD)and multi-infarct dementia(MID).Method:Twenty eight patients with AD and 30 patients with MID were exam-ined by transcranial Doppler(TCD)to detect the velocity of cerebral blood stream. Results:The veloc-ties of cerebral blood streams in these two groups were significantly lower than normal control subjects(P<0.05).But there was no significant difference between AD and MID group (P>0.05).The ab-normal rate of TCD in the AD group was 78.1%,28.6%of them had intracranial vessel stenosis,42.9%had extracranial vessel stenosis,and 7.1%had left middle cerebral artery occlusion. These re-sults indicated that the pathological changes of vasculature in these two groups were similar. Discus-sion: Local cerebral blood stream in patients with AD was reduced,especially in the frontal commissurearea. This finding was compatible with that obtained by cerebral tomography(SPECT).A MRI studyfound that 89%patients with AD had bilateral symmetrical lesions around the cerebral ventricles. Thiswas similar to the abnormal rate of cerebral blood stream of TCD in patients with AD in this study. Al-though the pathological changes of vasculature in AD and MID were similar, the relationship betweenthese changes and cerebral atrophy in AD remains to be examined.

关 键 词：早老性痴呆 经颅多普勒 病理 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学]