HCV HBV感染与肝细胞性肝癌  

HCV, HBV Infection and Hepatocellular Carcinoma

作　　者：孟宪镛[1] 姚登福[1] 倪润洲[1] 吴建新[1] 葛政举[1] 黄介飞[1] 伊索进 清水一郎[2] 

机构地区：[1]江苏南通医学院附院,南通226001 [2]日本德岛大学

出　　处：《临床消化病杂志》1995年第2期51-53,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：调查了肝癌高发地区不同肝病患者中丙型肝炎病毒(HCV)感染率。慢性肝病患者绝大多数已被乙型肝炎病毒(HBV)感染。HCV第二代抗体阳性率,肝癌7.3％,肝硬化6.6％,慢性肝炎6.6％和急性肝炎3.4％。两种病毒的复合感染率,肝癌5.1％,肝硬化1.7％,慢性肝炎3.9％和急性肝炎1.1％。在38例HCV抗体阳性的慢性肝病患者中,ALT异常84.2％,有输血史者占57.9％,HCV-RNA阳性率为71.1％。本研究的资料分析提示,在肝癌高发地区尽管HCV抗体阳性率较低,但HCV感染也是肝癌发生的重要病因之一。The incidence of antibody to hepatitis C virus (HCV) was investigated in patients with liver diseases in a high risk region for hepatocellular carcinoma (HCC). Most of the patients with chronic liver diseases were infected with hepatitis B virus(HBV). The incidence of antibody to HCV (second generation antibody) was 7. 3% in HCC, 6.6% in liver cirrhosis, 6.6% in chronic hepatitis and 3.4% in acute hepatitis. The incidence of HCV plus HBV coinfection was 5.1% in HCC,1.7% in liver cirrhosis, 3.9% in chronic hepatitis and 1.1% in acute hepatitis. Of 38 anti-HCV positive patients with chronic liver disea.ses, 84.2% had an abnormal ALT level, 57.9% had a history of blood transfusion and 71.1% were positive for HCV-RNA. Although the incidence of anti-HCV was low in the high risk region for HCC, these data suggest that HCV infection is one of the important aetiological factors for HCC.

关 键 词：丙型肝炎病毒 乙型肝炎病毒 感染 肝癌 肝细胞癌 

分 类 号：R735.702[医药卫生—肿瘤] R512.6[医药卫生—临床医学]