白细胞淤滞和维甲酸综合征：急性早幼粒细胞白血病早期死亡原因分析（附5例报告）  

Leukostasis and Retinoic Acid Sydrome: Analyses of the Causes Leading to Early Deathes in Acute Promyelocytic Leukemia(Report of 5 Cases)

作　　者：陆德炎[1] 陈唤青[1] 吴芳颐[1] 顾桂兰[1] 徐瑞容[1] 杨锦媛[1] 

机构地区：[1]南通医学院附属医院血液科

出　　处：《临床血液学杂志》1995年第2期59-62,共4页Journal of Clinical Hematology

摘　　要：５２例初诊ＡＰＬ患者单用全反式维甲酸（ＡＴＲＡ）治疗，其中５例在治疗后１月内早期死亡。除１例因ＡＰＬ本身严重的血小板减少所致的颅内出血外，其余４例死于与ＡＴＲＡ治疗相关的白细胞淤滞或维甲酸综合征。结合有关文献复习了这些严重合并症的临床表现和发病机理，并提出初步的处理意见。Fifty two patients with newly diagnosed acute promyelocytic leukemia(APL) were treated with alltrans retinoic acid (ATRA)alone. Five cases of them died early within one month after starting of this therapy. Four patients died of leukostasis or retinoic acid syndrome related to ATRA treatment, except that one of intracranial hemorrhage resulting from severe thrombocytopenia associated with APL itself. The clinial manifestations and pathogenesis of these serious compliactions are reviewed consulting the relevant literatures, and the preliminary opinions about management are proposed.

关 键 词：白细胞淤滞 维甲酸 综合征 白血病 急性 

分 类 号：R733.71[医药卫生—肿瘤]