犬脑梗塞模型的CT和病理研究  

CT and pathologic study on experimental cerebral infarction in the dog

作　　者：龚建平[1] 钱铭辉[1] 曹幼甫[1] 顾永平[1] 

机构地区：[1]苏州医学院附属第二人民医院CT室,苏州医学院病理学教研室

出　　处：《临床与实验病理学杂志》1995年第1期57-59,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：采用双硅柱栓塞法制作了９只犬脑梗塞模型。在２４ｈ之内，每隔４ｈ行ＣＴ检查一次，并定时将犬处死，进行病理研究，结果发现：ＣＴ上梗塞灶出现低密度改变的时间为栓塞后８～１６ｈ，与细胞内外液体量的增多有关；灰质区的神经细胞易产生缺血坏死性改变，故早期脑梗塞的低密度改变首先出现在灰质区；最低ＣＴ值的测定能更正确地反映早期梗塞灶的密度改变。Experimental cerebral infarction was created in 9 dogs using double silicone embolization method. Within 24 hours, the CT examinations were performed per 4 hour and the dogs were killed at fixed intervals for pathologic study. The results showed that the hypodensity of cerebral infarction on CT occured at 8￣12 hours after ictus,which was related to the increment of intraand/or extra-cellular liquid. The nerve cells at grey substance were vulnerable to ischmia, so the hypodensity of early infarction occured at first at grey substance. The measurement of the lowest CT value could manifest the hypodensity of early cerebral infarction more accurately.

关 键 词：早期脑梗塞 犬 CT 病理学 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]