不同丝裂原和治疗方法对胃癌肿瘤坏死因子的影响  

Effect of TNF on Patients of Carcinoma of Stomach byseveral Mito-gents and Treatment

作　　者：刘小朋[1] 张信[1] 陈紫榕[1] 张国安[1] 林华[1] 郑英[1] 

机构地区：[1]解放军第476医院免疫研究室

出　　处：《免疫学杂志》1995年第4期249-252,共4页Immunological Journal

摘　　要：采用ＥＬＩＳＡ法测定的２２名进展期胃癌患者和２０名健康献血员血浆ＴＮＦ含量分别为１９．２±１５．２和４．８±１．４ｎｇ／ｍｌ，前者比后者升高显著（Ｐ＜０．０５）。用ＰＨＡ、ｒＩＬ－２和ＴＦＤ单独与联合诱导的ＬＡＫ细胞培养上清ＴＮＦ含量，胃癌患者均比献血员高，有显著性差别（Ｐ＜０．０５）；联合诱导组优于单独诱导组，有显著性差异（Ｐ＜０．０５）．综合治疗（手术＋化疗＋中药＋复合细胞因子）和单一治疗均可使ＴＮＦ进一步升高。但综合治疗组优于单一治疗组（Ｐ＜０．０５），这对胃癌治疗有指导作用。The contents of tumor necrosis factor(TNF) in blood plasma from 22 patients with advancingcarcinoma of stomach and 20 healthy donors were detected by ELISA. The results showed that the contents ofTNF from the former(19. 2±15. 2ng/ml)were significantly higher than that from latter(4.8±1. 4ng/ml)(P<0. 05).The contents of TNF from patients with carcinorma of stomach which in culture supernatant oflym-phokine-activated killer(LAK)was induced by phytohemagglutinin(PHA ),recombinant interleukin-2, andthymic factor D(TFD),respectively or synergeticaly were higher than that from donors(P<0. 05).And syn-ergy induced TNF was higher than that of respective one(P<0. 05).Although operations(O),chemotherapies(CT),chinese medicines(CM)and complex cytokines(CC) respectively may cause all increase in TNF fromthe patients with carcinoma of stomach,but the contents of TNF after synergy treating with O+CT+CM+CC showed a significantly increase as compared with that of alone group (P<0.05).These results suggestthat the findings may be taken as a guide in treating the carcinoma of stomach.

关 键 词：肿瘤坏死因子 胸腺因子D 白细胞介素-2 胃肿瘤 

分 类 号：R735.205[医药卫生—肿瘤] R976[医药卫生—临床医学]