常压缺氧对大鼠肺组织β和α_1肾上腺能受体数目的影响  

The effect of normobaric hypoxia on the density of β and α_1 adrenoceptors in the rat lung

作　　者：谢剑鸣[1] 薛全福[1] 王立荣[1] 

机构地区：[1]中国医学科学院基础医学研究所病理生理研究室

出　　处：《中国病理生理杂志》1989年第5期261-265,共5页Chinese Journal of Pathophysiology

基　　金：国家"七;五"攻关的重点项目

摘　　要：本文观察常压缺氧性肺动脉高压对大鼠肺组织β和α_1受体的影响。动物分为对照组、缺氧1天和1、2、4周共5组,以观察不同缺氧时间大鼠肺β和α_1受体的动态变化规律。结果表明缺氧1天组大鼠肺β受体从对照组的299.7±23.4((?)±SD,下同)减少到234.4±73.9fmol/mg蛋白(P<0.05);缺氧1周时增至332.2±21.7(P<0.05);缺氧2、4周再次减少,分别为263.7±39.0,247.4±34.8(均P<0.05),β受体表现为减少、增加、再减少这样一种动态的变化。缺氧时α_1受体的变化与β受体不同。缺氧1天时α_1受体从对照组161.0±49.8增至277.2±24.2fmol/mg蛋白(P<0.01),缺氧1、2周分别为185.0±24.5,167.1±23.6,略高于正常对照组。缺氧4周时明显增加,为246.2±41.4(P<0.01)。α_1受体在缺氧时似乎都倾向于增加的趋势。无论是肺β还是α_1受体,缺氧前后亲和力(Kd)均无明显变化。β受体兴奋使肺血管舒张,α_1受体兴奋使肺血管收缩。缺氧时β受体的减少和α_1受体的增加都能促进肺血管的收缩,故这一变化在缺氧性肺动脉高压的发生、发展中可能具有一定的作用。The rats were kept in normobaric hypoxic chamber(O_2=10%) for 24 hours or 1,2,4 weeks(6 hrs./day, 6day/wk.). The adrenoeeptors of lungs were measured by binding study. The result showed that The beta adrenoceptors decreased by 24 hours of hypoxia and unexpectedly increased at 1 week of hypoxia. The exposure to hypoxia for 2 and 4 weeks led to a decrease in beta adrenoceptors again. By contrast, the alpha adrenoceptors increased markedly at 24 hours and 4 weeks of hypoxiao A higher, but not significant density of alpha_1 adrenoceptors was also found at 1 and 2 weeks of hypoxia. The affinity of beta and alpha_1 adrenoceptors did not change after hypoxia. The data indicated that the changes in adrenoceptors induced by hypoxia may play a role in the development of hypoxic pulmonary hypertension.

关 键 词：缺氧症 受体 肾上腺素能 肺 鼠 

分 类 号：R363.13[医药卫生—病理学]