消化性溃疡的治疗及远期疗效观察  

THE LONG-TERM RESULT OF TREATMENT OF PEPTIC ULCER

作　　者：赵世民[1] 梁玉珍[1] 贺建平 

机构地区：[1]中国人民解放军兰州军区总医院

出　　处：《内镜》1995年第4期203-205,共3页

摘　　要：本文报告ＣＢＳ甲氰咪胍雷尼替丁对１６２例消化性溃疡伴幽门螺杆菌阳性的治疗及远期疗效观察，结果：ＣＢＳ对ＨＰ的转阴率（９５％）显著高于甲氰咪胍（２３％）和雷尼替丁（２２％）。一年后ＨＰ阳转率ＣＢＳ组显著低于其它两组，三组分别为５％，１００％和９０％（Ｐ＜０．００１）。消化性溃疡治愈率三组之间无显著差异，分别为８０％、８４．６％和７８％（Ｐ＞０．０５）。但一年以后溃疡复发率ＣＢＳ组（１２．５％）显著低于甲氰咪胍（７１．５％）和雷尼替丁（５０％）（Ｐ＜０．００１）。伴随慢性胃炎好转率及活动性胃炎消失率ＣＢＳ组也优于其它两组。结论：ＨＰ感染与溃疡发生，延迟愈合及复发有密切关系；清除ＨＰ有助于溃疡愈合，改善胃窦炎症，降低溃疡复发率。One hundred sixty two cases of peptic ulcer with helicobacter pylori infection were divided into three groups randomly. Each group was treated with CBS cemitidine and ranetidine respectively. The HP clearance rate of CBS group was 95%, Cemitidine 23%, ranetidine 22%. After a year follow-up, HP positive rate of CBS group was 5%, cemitidine 100%,ranetidine 90%. There was a significant difference between CBS and other two groups(P<0.001 ). The ulcer healing rate of CBS group was 80%,cemitidine 84.65,ranetidine 78% (P>0.05). But after a year ulcer recurrence rate of CBS group (12.5%)was significantly lower than other two groups (71.5% & 50%).(P<O. 001). The result shows that CBS may effectively inhibit HP growth and reduce ulcer recurrence. Conclusion;There is a close correlation between HP infection and peptic ulcer as well as chronic gastritis. Clearing of HP may improve ulcer cure ,alleviate inflammation of gastric antral mucosa and reduce ulcer recurrence CBS is a good inhibitor to HP.

关 键 词：消化性溃疡 幽门螺杆菌 疗效 药物疗法 

分 类 号：R570.5[医药卫生—消化系统]