十二指肠溃疡病患者幽门螺旋菌感染与胃酸及胃泌素关系  

ANTRAL HELICOBACTER PYLORI, GASTRIN AND GASTRIC ACID SECRETION IN PATIENTS WITH DUODENAL ULCERS

作　　者：石建群 黄介飞 孟宪镛 

出　　处：《南通医学院学报》1995年第2期175-177,共3页ACTA Academiae Medicinae Nantong

摘　　要：４０例活动性十二指肠球部溃疡（ＤＵ）病人均伴有胃窦炎，２８例胃窦部幽门螺旋菌（ＨＰ）阳性，１２例阴性。基础胃酸分泌（ＢＡＯ）、五肽胃泌索刺激后的高峰胃酸分泌（ＰＡＯ）以及空腹和餐后１小时血清胃泌素水平，在ＨＰ（＋）组均明显高于ＨＰ（－）组（Ｐ＜０．０１～０．０２）。经治疗，１０例ＨＰ（＋）患者复查，发现ＨＰ清除后空腹和餐后血清胃泌素均显著下降（Ｐ＜０．０１），但平均ＢＡＯ和ＰＡＯ下降不明显（Ｐ＞０．０５）。研究结果提示，ＨＰ系通过刺激胃泌素分泌及胃酸增高而引起ＤＵ，ＨＰ清除后血清胃泌索下降，ＰＡＯ无明显下降。鉴于此，采用杀灭ＨＰ药物结合Ｈ２受体阻断剂治疗，可望加速溃疡愈合。We studied 40 patients with active duodenal ulcers,all of them had antrum gastritis,28were positive for Helicobacter pylori and 12 hegative on antrum. Basal acid output (BAO),peak secretion of acid stim ulated by pen tagastrin (PAO),Basal serum gastrin and postprandial serum gastrin concentrations are measured.The four items are significantly higher in patients positive for H pylori than in those negative for the organigm. Arter treatment,9 paticnts eradicatcs H pylori,Basal grastrin and postprandial gastrin concentrations fell,However,BAO and PAO unchanged.Therefore,H pylori increasc antral gastrin relapse and gastric acid secretion,then causes duodenal ulcers.Using treatments that eradicate H pylori and H2-receptor's antogonist,We will cure duodenal ulcer faster.

关 键 词：幽门螺旋菌 胃泌素 胃酸 十二指肠溃疡 

分 类 号：R573.102[医药卫生—消化系统]