雄性F344大鼠睾丸间质细胞瘤的癌前期病变及其生物学意义  

THE SIGNIFICANCE OF THE BIOLOGY OF PRENEOPLASTIC ON MALE FISCHAR 344 RATS WITH TESTICULAR INTERSTITIAL CELL TUMOR

作　　者：周光兴[1] 何剑秋[1] 赵为之[1] 佘振珏[1] 杨幼明[1] 杨俊华[1] 

机构地区：[1]上海医科大学实验动物部

出　　处：《上海医科大学学报》1995年第4期258-261,共4页Journal of Fudan University(Medical Science)

摘　　要：采用全自动图象分析仪结合ＨＥ染色和免疫组织化学染色，对已有不育史的５个年龄组雄性Ｆ３４４大鼠的睾丸进行形态定量研究及病理形态分析。结果提示：睾丸间质细胞为增生为睾丸间质细胞瘤的癌前期病变，两者对引起雄性Ｆ３４４大鼠不育均有重要意义。In this paper,the male F344 sterility rats were taken from 5 age group, using morphometric measurements of seminiferous tubulesand immunohistochemical staining with anti-rat lactate dehydrogenase isozyme-C (LDH-C4) taken measure of activity in the testicular. The results showed that very clear differences were found in each age group.The results indicated that interstitial cell hyperplasia and seminiferous tubules atrophy are preneoplasia of testicular interstitial celI tumor and may be considered important causes of the male F344 rats sterility. The male F344 rat for the studying the human testicular interstitial cell tumor is the best animal model iof choice.

关 键 词：间质细胞癌 形态定量学 癌前期病变 睾丸肿瘤 

分 类 号：R737.210.2[医药卫生—肿瘤]