人胎肌来源的生物因子抗肿瘤活性实验研究  

Study of antitumor activity of biological factor in conditioned medium prepared from fetal striated muscle

作　　者：张家兴[1] 朱宝珍[1] 崔玉芳[1] 王东根[1] 葛忠良[1] 

机构地区：[1]军事医学科学院放射医学研究所

出　　处：《实用肿瘤杂志》1995年第1期39-41,共3页Journal of Practical Oncology

摘　　要：研究人胚胎横纹肌条件培养液产生的生物因子（ＡＴＦ－ＦＭＣＭ）抗肿瘤活性。观察发现ＡＴＦ对８种肿瘤细胞株体外增殖有抑制作用。对ＢＧＣ－８２３等６种瘤细胞的抑制率均在５２％～９４％之间。其中对ＢＧＣ－８２３、Ｖ－７２２１和Ｈｅｌａ３株瘤细胞的抑制率最高，分别为９４％，９３％和８５％。整体抑瘤实验证实，ＡＴＦ能明显减轻Ｓ－１８０荷瘤小鼠腹水的严重程度，生存时间延长，并能有效抑制ＬＡ－７９５肺腺瘤荷瘤小鼠的肺转移。文中还分析了ＡＴＦ的生化特性和抑瘤机理。Antitumor activity of biological factor(ATF) in conditioned medium prepared from fetal striated muscle had been studied.The suppresion of tumor cell proliferation of 8 specis with ATF in vitro was demonstrated.The rate of suppresion was 52%～94% in BGC·823 and tumor cell of other 5 specis.The suppresion ratebeing highest in BGC-823,V-7221 and Hela tumor cells was 94%,93% and 85% respectively.ATF reduced the amount of ascites and prolonged the survival in mice beared with S-180.ATF inhibited the pulmonary metastasis in mice beared with of LA-795 lung adenocarcinoma.The biochemical property of ATF and its antitumor mechanism are discussed in this paper.

关 键 词：抗肿瘤生物因子 人胚 横纹肌 培养液 生物疗法 

分 类 号：R73－36[医药卫生—肿瘤]