不同剂量枢复宁对恶性血液病患者化疗后呕吐的防治作用比较  

Comparison of anti-emetic efficacy of different doses of ondansetron in chemotherapy for patients with malignant hematolotic diseases

作　　者：李汉冲 茹脐华 叶娴 张晓黎 谭洁 张明 

机构地区：[1]苏州市第四医院血液科

出　　处：《实用肿瘤杂志》1995年第3期149-151,共3页Journal of Practical Oncology

摘　　要：对８６例恶性血液病患者进行随机分组，甲组４２例，乙组４４例，采用双盲法于化疗前予不同剂量枢复宁防治恶心呕吐。结果两组对呕吐的完全控制和基本控制率分别为甲组９０．５％，乙组８８．７％（Ｐ＞０．０５）。对化疗后２４小时内恶心的控制两组亦无显著差异。提示枢复宁单剂量静注可取得较好止吐效果。A total of 86 patients with malignant hematologic disease recieving chemotherapy participated in the evaluation of the efficacy of ondansetron for the prevention of acute nausea and emesis. Complete and major control of acute emesis was achieved in 90.5% of the patients in group Ⅰ, and 88.7%,in groupⅡ(both P>0. 05).ninety per cent of the patients in group Ⅰ,and 84% in group Ⅱ experienced no or mild nausea during the 24-hour observation peried (both P>0. 05) The authous drew the conclusion that a single irtraverous dose of 8mg of ordansetron given prior to chemotherapy is as effective as a comtinuous infusion in the prophylaxis of acute emesis.

关 键 词：枢复宁 呕吐 白血病 淋巴肉瘤 多发性骨髓病 

分 类 号：R733.705[医药卫生—肿瘤]