白细胞介素2增强肿瘤坏死因子对人胃癌细胞株的抑制作用  

Inhibitory effect of tumor necrosis factor and interleukin-2 on gastric carcinoma cell line

作　　者：厉有名[1] 陈卫星[1] 孙永良[1] 黄怀德[1] 

机构地区：[1]浙江医科大学附属第一医院

出　　处：《实用肿瘤杂志》1995年第3期171-172,共2页Journal of Practical Oncology

基　　金：浙江省卫生厅科研基金

摘　　要：采用体外细胞培养法观察重组肿瘤坏死因子（ｒＨ－ＴＮＦ）和白细胞介素２（ＩＬ－２）对人类胃癌细胞株（ＭＫＮ）的抑制作用。结果表明，肿瘤坏死因子对ＭＫＮ胃癌细胞有直接抑制作用，抑瘤效应与ＴＮＦ的浓度呈正相关（ｒ＝０．９６８，Ｐ＜０．０１）；ＩＬ－２无直接抑制作用，但能增强ＴＮＦ的抑瘤作用，其机理可能与白细胞介素２诱导肿瘤细胞表达ＴＮＦ受体的作用有关。The inhibitory effect of tumor necrosis factor(TNF)and interleukin-2(IL-2)on the human gastric carcinoma cell line(MKN) was studied by using in-vitro cell culture.The results indicated the direct inhibitory effect on MKN cells became stronger with the increase in the concentration of TNF.IL-2 yielded no direct inhibitory effect,but could enhance the effect of TNF,which might be related to the inducation of expression of TNF receptor on the tumor cells by IL-2.

关 键 词：肿瘤坏死因子 白细胞介素 细胞株 胃肿瘤 

分 类 号：R735.205[医药卫生—肿瘤]