47例急性白血病患者T细胞及其亚群免疫应答能力测析  

Changes of immunological responsiveness and T lymphocytes' subsets in Patients with acute leukemia

作　　者：李鸣[1] 章翰[1] 

机构地区：[1]同济医科大学实验医学研究中心

出　　处：《中国免疫学杂志》1989年第2期100-102,共3页Chinese Journal of Immunology

摘　　要：本文报道了对47例急性白血病患者(急淋18例、急粒29例)外周血T细胞对PHA刺激反应及OKT单克隆抗体玫瑰花试验T细胞亚群的检测。其结果为急淋、急粒患者的细胞免疫功能均低于健康人,其中急淋患者的T细胞对PHA刺激反应(用SI表示)及T细胞亚群降低的程度均大于急粒患者。急性白血病缓解期患者诸项检测均与健康成人接近,而未经治疗者,治疗中期及预后极差:临床表现上则有出不同程度的免疫抑制。This study reported the lymphocyte proliferation to PHA and T lymphocytic subsets with OKT series McAb rosette lest in the peripheral blood of 22 healthy adults and 47 cases of acute leukemic patients. The results showed that lymphocyte proliferation to PHA(signaled with stimulation index, SI) and the count(%) of T cell subsets were found to be lower in lymphocytic leukemic patients than that in granulocytic leukemic patients. During the period of remission, the parameters above approached to that of the healthy adults and the immune responses were suppressed to a different extent prior to and during chemotherapy as well as in lethal patients.

关 键 词：白血病 T细胞 免疫 应答力 

分 类 号：R733.7[医药卫生—肿瘤]