卵巢内胚窦瘤的治疗与预后（附30例病例分析）  

Treatment and Prognosis of Endodermal Sinus Tumors of Ovary:An Analysis of 30 Cases

作　　者：成文彩[1] 漆秀梅[1] 蔡桂茹 顾美皎[1] 李静[1] 

机构地区：[1]同济医科大学附属同济医院妇产科

出　　处：《同济医科大学学报》1995年第4期304-307,共4页Acta Universitatis Medicinae Tongji

摘　　要：１９７５年１月～１９９２年１２月收治卵巢内胚窦瘤３０例，为同期卵巢恶性肿瘤５２９例中的５．６７％。３０例中现健存１４例，１年生存率为６３．３％，２２年生存率４６．７％，３０例中１３例在１９７５～１９８４年发病，其１年生存率４６．２％，≥２年生存率１５，４％；而１９８５～１９９２年的１７例中，１年生存率７６；５％，≥２年生存率７０．６％，两个年度比较差异有极显著意义（Ｐ＜０．０１）。其临床分期、残余瘤灶与预后密切相关（Ｐ＜Ｏ．０１），术后不化疗、间歇期延长或过早中断治疗是复发、恶化的主要原因，手术范围的大小与预后无明显差异（Ｐ＞０．０５）。patients with endodermal sinus tumors(EST)of ovary were treated from January 1975 to December 1992,which amounted to 5.67%of 529 malignant ovarian tumor during the same time,The average age of patients was 20.6 years.The rate of follow-up was 100%. 14 of 30 patients are alive at end of observation period and they had 63.3% oneyear survival and 46.7%had≥two-year survival.13 of 30 patients had relapse during 1975-1984 with one-year survival of 46.2%and 15.4%had≥two-Vear survival.From 1985-1992,in 17 patients 76.5%had one-year survival and 70.6%≥two-year stirvival.There was a signlficant difference between stirvival rates of the two periodtq(P<0.01).Prognosis was closely related to clinical stage and volume of residual tumors(P<0.01).The main causes of recurrence or deterioration were failure to receive chemotherapy after operatiOn,prolongation of chemotherapy interval and premature discontinuation of chemotherapy.No relationship was found between the extent of operation and prognosis(P>0.05).

关 键 词：卵巢肿瘤 内胚窦瘤 手术 药物疗法.联合 甲胎蛋白 

分 类 号：R737.310.5[医药卫生—肿瘤]