慢性肝病患者血清Ⅲ型前胶原及透明质酸的变化  

The Changes of Serum ProcollagenⅢ,Hyaluronic Acid in Chronic Hepatic Diseases

作　　者：唐望先[1] 刘宏群[1] 张文英[1] 虞涤霞[1] 李绍白[1] 

机构地区：[1]同济医科大学附属同济医院肝病研究所,武汉市第七医院

出　　处：《同济医科大学学报》1995年第5期339-341,共3页Acta Universitatis Medicinae Tongji

摘　　要：采用放射免疫法测定６８例慢性肝病患者血清Ⅲ型前胶原（ＰＣⅢ）、透明质酸（ＨＡ）水平及部分肝功能的变化．结果表明：慢性活动性肝炎（ＣＡＨ）、肝硬化（ＬＣ）及肝癌（ＨＣＣ）患者血清ＰＣⅢ、ＨＡ均显著高于正常组（Ｐ＜０．０１），而慢性迁延性肝炎ＰＣⅢ、ＨＡ升高不显著．血清ＰＣⅢ与γ－球蛋白呈正相关．另外，ＨＡ水平与部分肝功能损伤程度趋于一致，与γ－球蛋白有相关性．提示：血清ＰＣⅢ、ＨＡ检测可作为肝纤维化、肝硬化的血清学指标，且可作为动态观察肝纤维化发展过程的临床指标．ＨＡ可反映慢性肝功能损伤程度．The procollagen Ⅲ(PCⅢ), hyaluronic acid(HA)were measured with radioimmunoassay(RIA)in 68 patients with various chronic hepatic diseases. Some parameters of the hepatic function were also measured. The results showed that the serum PC Ⅲ,HA in patients with chronic active hepatitis(CAH), cirrhosis of liver (LC)and hepatocellular carcinoma hepatitis(CAH), cirrhosis of liver(LC) and hepatocellular carcinoma(HCC)were significantly higher than those in normal group(P<0.01). While there was no significant increase of PC Ⅲ and HA in chronic persisting hepatitis(CPH). Furthermore, the HA level was in accordance with the degree of hepatic functional damage. We concluded that PC Ⅲ, HA may be taken as indexes indicating the degree of hepatic fibrosis and cirrhosis PC Ⅲ.HA might also have certain value in the differentiating diagnosis between CPH and CAH.Moreover, HA may reflect the degree of hepatic functional damage.

关 键 词：肝疾病 Ⅲ型前胶原 透明质酸 肝功能试验 

分 类 号：R575.02[医药卫生—消化系统]