我国肝病患者HCV感染的血清流行病学研究  

Seroepidemiological Investigation of Hepatitis C Virus Infection in Patients with Liver Diseases in China

作　　者：杨东亮[1] 李淋[1] 赵西平[1] 汪由坤[1] 喻植群[1] 郝连杰[1] 

机构地区：[1]同济医科大学附属同济医院临床免疫研究室

出　　处：《同济医科大学学报》1995年第6期429-432,共4页Acta Universitatis Medicinae Tongji

基　　金：国家"八.五"攻关项目

摘　　要：应用第二代抗ＨＣＶ试剂对我国不同地区肝病患者血清抗ＨＣＶ进行了检测，同时调查了ＨＢＶ和ＨＡＶ感染状况。２０１６例肝病患者血清中抗ＨＣＶ检出率为１２．２５％，ＨＢＶｍ检出率为７４．５５％，抗ＨＡＶ－ＩｇＭ检出率为２９．３１％。各型肝病患者抗ＨＣＶ检出情况分别是：急性肝炎６２／７５２（８．２４％）；慢性迁延性肝炎４８／５４１（８．８７％）；慢性活动性肝炎９３／５２３（１７．７８％）；慢性重症肝炎５／３２（１５．６３％）；肝硬化３４／１４３（２３．７８％）；肝癌５／２５（２０．００％）。对不同年龄组肝病患者抗ＨＣＶ检出率的比较表明，抗ＨＣＶ检出率随患者年龄增加而增高。受血史及其它经血液暴露史与ＨＣＶ感染密切相关，但仍有近半数肝病患者ＨＣＶ感染途径不明。各型肝病患者中仅４７／２０１６（２．１３％）为单纯ＨＣＶ感染，其它ＨＣＶ感染者则为重叠感染。不同地区肝病患者血清抗ＨＣＶ检出率间差异较大（２．１５％～３０．９５％），北方地区较高，对其影响因素进行了探讨。Using the second generation anti-HCV ELISA kits, the antibodies to hepatitis C virus have been detected in sera of patients with liver diseases in different areas of China, meanwhile the status of HBV and HAV infection has also been investigated. Of 2 016 liver disease patients, 12. 25%were positive for anti-HCV, 74. 55%were positive for HBV marks, while anti-HAV IgM was detected in 29.31%. The prevalence of anti-HCV in different groups of patients was as follows: 8. 24%among acute hepatitis,8.87%among chronic persistant hepatitis, 17.78%among chronic active hepatitis, 15. 63%among chronic severe hepatitis, 23.78%among liver cirrhosis and 20.00%among hepatocellular carcinoma, Furthermore, the positive rate of anti-HCV among elder patients was higher than that among the younger ones. HCV infection was closely related to transfusion and other direct exposures to blood, but inapparent transmission of HCV was documented in almost fifty percent of the patients. Most of HCV infected patients in this study were superinfected with HBV and /or HAV, only 2.13%of the subjets were infected with HCV singly. The differences of anti-HCV prevalence in patients from different areas of China were apparent, showing a tendency that the anti-HCV prevalence was higher in northern part and lower in southern part of China.

关 键 词：肝疾病 丙型肝炎病毒 血清 流行病学 

分 类 号：R575.03[医药卫生—消化系统] R512.630.1[医药卫生—内科学]