急性白血病的甲襞微循环及临床意义  

Nailfold Microcirculation Changes in Patients with Acute Leukemia

作　　者：谢波[1] 邓友安[1] 颜维仁[1] 高丹[1] 袁永强[1] 

机构地区：[1]四川省重庆市第二人民医院血液科

出　　处：《微循环学杂志》1995年第1期14-15,共2页Chinese Journal of Microcirculation

摘　　要：对４０例急性白血病（ＡＮ）患者进行甲襞微循环观察，按田牛提出的加权积分法进行综合定量分析。ＡＬ患者甲襞微循环各类积分值均显著高于正常对照组（Ｐ＜０．００１）。化疗后总积分值显著升高（Ｐ＜０．００１），缓解期显著下降（Ｐ＜０．０５）。总积分值与血红蛋白浓度、血小板计数均呈显著负相关（γ分别为－０．３１７和－０．２４１，Ｐ分别＜０．０１和０．０５）。甲襞微循环观察分析有助于深入研究ＡＬ患者病情变化和监测微血管对化疗药物毒性的反应。Nailfold microcirculation in 40 patients with acute leukemia were investigated and evaluated with multiple quantitative evaluation method proposed by Tian Niu.The score values of nailfold microcirculation in the patients were higher than that of control group statistically(P<0.001).Total score value rise remarkably after chemotheropy(P<0.001) and dropped down markedly in the remission period(P<0.05).There was a striking negative correlation between total score and hemoglobin level(r=-0.317,P<0.01),and the platelet count(r=-0.241,P<0.05).The results indicate that the observation and analysis of nailfold microcirculation in patients with acute leukemia are helpful to researching into the change of disease state and monitoring the reaction of blood vessels to chemotheropeutic durg.

关 键 词：白血管 急性 甲襞微循环 微循环 

分 类 号：R733.710.2[医药卫生—肿瘤]