辐射和高温应激条件下对大鼠体内生物活性物质的影响及发生机制的初步探讨  

PRELIMINARY PROBE OF INFLUENCE OF RADIATION AND HIGB TEMPERRATURE STRESSOR ON BIOACTIVE SUBSTANCE IN RATS AND ITS MECHANISM

作　　者：吕慧敏[1] 张伟[1] 关腾 董金婵 郭亦超 贺秋晨 吴曙光 

机构地区：[1]卫生部工业卫生实验所

出　　处：《现代预防医学》1995年第1期5-8,共4页Modern Preventive Medicine

基　　金：全军医学科学基金

摘　　要：Ｗｉｓｔａｒ大鼠，经过０．６，０．８，１．０Ｇｙ６０Ｃｏ射线一次均匀全身照射，用放免分析的方法测定血浆血管紧张素Ⅱ（ＡⅡ）和醛固酮（ＡＬＤ），以及经过３３℃，４４℃，４８℃高温受热处理后，用放免分析的方法测定血浆血管紧张素Ⅱ、醛固酮和皮质醇的变化。结果表明：照射后大鼠血浆血管紧张素Ⅱ未出现应激性升高，醛固酮只在１．０Ｇｙ剂量照射后３小时出现应激性升高；高温处理后，大鼠血浆血管紧张素Ⅱ及皮质醇有升高趋势，而醛固酮有降低的趋势。Measure angiotensin (AII)and aldosterone (ALD)with radioimmunoassay in blood plasma of Wistar rats after exposing an single whole-body 61Co gamma rays radiation, doses are 0.6, 0.8,1.0 Gy respectively. And with the same method, measure the changes of AII, ALD and cortisol in blood plasma after treating with high temperature of 38, 44, 48 centigrade. The results show that All in blood plasma does not increase after irradiation. ALP increases only after 3 hours at dose of 1. 0 Gy. There are increase trend of AII and cortisol, and decrease trend of ALD after high temperature treatment.

关 键 词：辐射损伤 高温 应激 生物活性物质 

分 类 号：R818.740.2[医药卫生—放射医学] R594.102[医药卫生—临床医学]