实验大鼠矽肺纤维化扫描电镜观察  

STUDIES OF EXPERIMENTAL SILICOTIC RAT BY SEM

作　　者：杨青[1] 

机构地区：[1]华西医科大学公共卫生学院

出　　处：《现代预防医学》1995年第3期136-137,共2页Modern Preventive Medicine

摘　　要：本文采用非暴露式气管内注入法，对大鼠一次染石英尘５０ｍｇ，在染尘后１５、４５、９０、１８０和２７０天分批取样进行动态扫描电镜观察。结果显示，在实验早期肺泡腔内巨噬细胞聚集、成簇，Ⅱ型肺泡上皮细胞增生，部分转变为Ⅰ型上皮细胞，在肺泡间隔和肺泡壁上可见成纤维细胞，并分泌直径约０．０３μｍ的纤维，随着染尘时间延长，肺泡结构破坏，纤维增生相互交织呈网状和束状，导致肺间质和实质纤维化。The experimental rats were divided control and silica group.5 0mg of silica were injected intratracheally in silica group, Samples of lung tissue were collected in 15,45,90,180 and 270 days after the injection, These samples were studied with SEM)Scanning electron microscope).The results showed fibro-blasts secrated fibre.The fibrosis was occuring not only in interstitial pulmonary fibrosis,but also in pulmonary parenchyma in early stage of experimental silicotic rats.

关 键 词：职业病 矽肺 肺纤维化 扫描电镜 病理 

分 类 号：R598.2[医药卫生—内科学]