肝硬化患者胆囊胆汁脂类、胆红素及金属元素代谢的研究  

Study on the bilirubin, lipids and metal elements in gallbladder bile in patients with liver cirrhosis

作　　者：朱江帆[1] 单礼成[1] 陈文华[1] 胡成进[1] 徐良[1] 

机构地区：[1]济南军区总医院,250031

出　　处：《新消化病学杂志》1995年第2期89-91,共3页

摘　　要：目的 观察肝硬化患者胆囊胆汁成份改变,分析与肝硬变胆石多发的关系。 方法 术中抽取24例肝硬化患者胆囊胆汁,测定脂类、胆红素及金属元素钾、钠、钙、镁、铜、铁、锌。 结果 肝硬化胆囊胆汁中未结合胆红素水平明显增高,总胆汁酸、胆固醇、磷脂浓度和胆汁粘度明显下降。金属元素中钾、镁、铜、锌水平下降,铁含量显著升高。 结论 肝硬化胆囊胆汁具有明显成色素性结石趋势。因此,肝硬化胆汁成分改变是易于形成结石的基础。AIM To study the changes of the bile elements in patients with liver cirrhosis and analyse its relationship with the stone formation. METHODS Intraoperative aspiration of gallbladder bile was performed in 24 patients with liver cirrhosis. The lipids, bilirubin and K, Na, Ca, Mg, Cu, Fe and Zn levels in the bile were determined.RESULTS Obviously elevated UCB level (P<0.02) and decreased TBA (P <0.001), TC (P<0.001), PL (P<0.05) and bile viscosity (P<0.001) were discovered. The bile K, Mg, Cu, Zn levels decreased (all P values less than 0. 01) and Fe increased (P < 0. 02) significantly in the cirrhotic patients.CONCLUSIONS The gallbladder bile in patients with liver cirrhosis is of obviously tendency to form the pigment stones. Thus the changes of bile composition in the cirrhotic patients are the basis of stone formation.

关 键 词：肝硬变 胆红素 脂类 金属元素 

分 类 号：R575.202[医药卫生—消化系统]