左心房压增高对血管紧张素转换酶影响的实验观察  

The Influence of Elevated Left Atrial Pressure on Angiotensin Converting Enzyme-An experimental Study

作　　者：屈正[1] 孙衍庆[1] 谭一忠 董培青[1] 毛斌[1] 张宏[1] 

机构地区：[1]首都医科大学附属北京安贞医院,中国医学科学院基础研究所病理生理教研室

出　　处：《心肺血管病杂志》1995年第2期97-98,共2页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：１５只家兔左剖胸右肺通气，其中Ａ组１０只阻断降主动脉３０分钟致左心房高压（３．７３±０．４１ｋＰａ），Ｂ组５只维持正常左房压３０分钟。结果Ｂ组动脉血浆血管紧张素转换酶（ＡＣＥ）活性无明显变化；Ａ组ＡＣＥ活性较前降低２８．４％（Ｐ＜０．０１），且与病理学上肺损伤改变相符合。本文认为测定ＡＣＦ活性可作为判断左心房高压引起的肺损伤的指标之一。Fifteen rabbits undergoing left thoracotomy and right lung ventilation were divided into two groups.In group A (10 cases),angiotensin converting enzyme (ACE) activity decreased significantly (P<0.01) which coincided with pathological changes in the lung,subsequent to left atrial pressure increased 3.73±0.41 kPa for 30 minutes during cross clamping of descending aorta.There were no clear aformentioned changes observed in group B (5 cases) with normal left atrial pressure.

关 键 词：血管紧张素 转换酶 左心房压力 实验 病理学 

分 类 号：R362[医药卫生—病理学]