高三尖杉酯碱注射液对兔青光眼滤过手术的作用  

Efficacy of Adjunctive Homoharringtonine on Glaucoma Surgery in Rabbits

作　　者：徐岩[1] 杨国华[1] 靳伟民[1] 陈克谦[1] 李建新[1] 

机构地区：[1]河南省眼科研究所青光眼实验室

出　　处：《眼科研究》1995年第4期224-227,共4页Chinese Ophthalmic Research

摘　　要：为证实高三尖杉酯碱脂质体用于兔滤过术失败是受脂质体制备的影响，还是高三尖杉酯碱（Ｈｏ－ｍｏｈａｒｒｉｎｇｔｏｎｉｎｅ，ＨＨＴ）自身的原因，就ＨＨＴ注射液对兔滤过术的作用进行了研究。结果显示，术后实验眼的平均眼压及平均滤泡得分与对照眼无显著性差异（Ｐ＞０．０５）。对照眼的滤泡于术后７天失败，实验眼的于术后９天失败。从术后５～２０天，实验眼与对照眼的巩膜瘘道阻塞率均为１００％。上述结果与作者应用ＨＨＴ脂质体的实验结果基本一致，显示ＨＨＴ注射液与ＨＨＴ脂质体一样未能抑制兔结膜成纤维细胞生长及胶原合成，未能提高青光眼滤过术的成功率。o confirm that the failure of glaucoma filtering surgery(GFS)with adjunctive Homoharringtonine(HHT)liposomes in rabbits in our former experiment was a result of preparation of liposomes or by HHT itself,we evaluated the efficacy of adjunctive HHT solution on GFS in rabbits in this study. Posterior lip sclerectomies were performed on both eyes of 16 rabbits. 0.075mg of HHT solution was given subconjuncti-vally in one eye of each of 16 rabbits on the first post-op day and every other day hereafter.The fellow eyes received subconjunctival normal saline post-op and served as control.The mean IOP was slightly lower and mean bleb scores were mildly improved in the treated eyes than that in the control eyes post-op,yet there was no significant difference(P>0.05).The bleb in the treated eyes failed in 9 days post-op and the bleb in the control eyes failed in 7 days.From day 5 to day 20,the rate of sclera fistula occlusion was 100/in both groups.These results were consistent with the experimental results of using HHT liposomes on GFS in rab-bits and showed that HHT solution like HHT liposomes can neither inhibit fibroblast proliferation and syn-thesis of collagen fibers nor enhance success rate of GFS in rabbits in our experiment.We thought that the main reason for the failure of adjunctive HHT may be relative to lower dose of administering HHT.

关 键 词：高三尖杉酯碱 青光眼 滤过性手术 

分 类 号：R775.05[医药卫生—眼科]