紫菜多糖对机体细胞的保护作用  

THE CYTOPROTECTION OF POLYSACCHARIDE FROM PORPHYRA YEZOENISIS UEDA

作　　者：周慧萍[1] 陈琼华[1] 

机构地区：[1]中国药科大学生物化学研究室

出　　处：《中国药科大学学报》1989年第6期340-343,共4页Journal of China Pharmaceutical University

摘　　要：小鼠ip紫菜多糖150mg/kg能对抗^(60)Coγ射线的辐射,存活率为对照组的1.8倍;对抗环磷酰胺引起的白细胞下降和微核增加,对抗率分别为79.60%和29.96%;对CCl_4所致的小鼠肝损伤SGPT升高有明显对抗作用,对抗率为68.04%;对肉瘤S-180有一定抑制作用,抑制率为47.55%;大鼠ip 180mg/kg,有较明显的对抗鹿角菜胶所致的炎症作用。正常小鼠ip、po 50mg/kg,3h后血糖分别下降58.45%和68.39%;对四氧嘧啶所致高血糖小鼠ip 50mg/kg,24h后血糖下降37.96%。Polysaccharide from Porphyra yezoensis Ucda (PP) (with a dose of ip 150mg/kg)had a marked antiradical effect on ^(60)Co γ radiation in mice, and the average survival time was 1.8 times as the control group; PP showed a remarkable antagonistic action to leukopenia and reduced the frequency of mieronuclci induced by eyclophosphamide, and the antagonistic rates were 79.60% and 29.96% respectively; PP (ip 180mg/kg) had anti-inflammatory effect in rats induced by siliquose pclvctia glum; PP showed a marked antagonistic action on the increase of SGPT caused by CCl_4 in mice, and the antagonistic rate was 68.04%. PP (ip and po 50mg/kg) reduced the blood glucose level in normal mice by 58.45% and 68.39% respectively 3h after administration; PP had a prevention effect on the alloxan-induced diabetic mice, after 24h of ip 50mg/kg, and the blood glucose level was reduced by 37.96%. PP also had antitumor activity on S-180, with a dose of ip 150mg/kg, and the antagonistic rate was 47.55%.

关 键 词：紫菜 多糖 细胞保护 

分 类 号：R285.5[医药卫生—中药学]