丁基苯酞对小鼠全脑缺血的保护作用  

EFFECT OF DL-BUTYLPHTHALIDE(NBP)ON MOUSE BRAIN ENERGY METADOLISM IN COMPLETE BRAIN ISCHEMIA INDUCED BY DECAPITATION

作　　者：冯亦璞[1] 胡盾[1] 张丽英[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》1995年第10期741-744,共4页Acta Pharmaceutica Sinica

基　　金：国家科委新药研究基金

摘　　要：观察了丁基苯酞（ＮＢＰ）对小鼠全脑缺血脑保护作用和脑能量代谢的影响。用Ｌｏｗｒｙ法测定脑乳酸，ＡＴＰ和磷酸肌酸（ＰＣｒ）的含量。结果表明，ＮＢＰ１１２．５或２５０ｍｇ·ｋｇ－１ｓｃ能明显延长断头或ｉｖ饱和ＭｇＣｌ２后喘息的时间；ＮＢＰ１５Ｏ或２００ｍｇ·ｋｇ－１ｓｃ能明显减少断头缺血后乳酸的升高和ＡＴＰ及ＰＣｒ的降低。实验结果提示，ＮＢＰ对缺血脑有保护和改善脑能量代谢的作用。The effects of NBP on gasping and brain energy metabolism after complete brainischemia in mice subjected to decapitation were in vestigated. The levels of ATP ,phosphocreatine(PCr)and lactate were determined by the method of Lowry. The data indicated that NBP at 112.5 or250 mg· kg-1 sc can significantly prolong the duration of gasping and at the dose of 150 or 200mg· kg-1 sc reduce the level of lactate and increase the levels of ATP and PCr after complete brainischemia。The results suggest that NBP may have brain protective action and improve ischemic brainenergy metabolism.

关 键 词：丁基苯酚 脑缺血 三磷酸腺苷 磷酸肌酸 乳酸 鼠 

分 类 号：R969.4[医药卫生—药理学] R743.310.5[医药卫生—药学]