氟哌酸的水分实验研究  

Experimental studies of the water contents in norfloxacin

作　　者：侯美琴[1] 任亚伟 曹小斐[1] 徐蓓蕾 

机构地区：[1]上海市药品检验所

出　　处：《中国药学杂志》1989年第9期536-538,共3页Chinese Pharmaceutical Journal

摘　　要：对氟哌酸原料采用差热扫描法、热重法、费休氏水分测定,红外吸收光谱,X-衍射等实验测试,证实本品在湿度高的条件下极易吸收水分,而形成1～20%不等的水合物。样品为干燥品时,能迅速吸收水分,而样品已达10%的水合物后,其吸收水分的速率就会减缓。The presence of water in Norfloxacinwas studied by differential scanning calori-metry,thermogravimetric analysis,Karl-Fischer titration,infrared spectroscopyand X-ray diffractometry.It was confirmedthat norfloxacin absorbed moisture easilyunder high relative humidity to form waterof hydration varying from 1～20% according tothe storage condition.It absorbs moisture r-apidly when the specimen is dry and whenthe absorbed water is over 10%,the rateof absorption is decreased

关 键 词：氟哌酸 水合物 药品检验 

分 类 号：R914.1[医药卫生—药物化学]