经裸鼠移植人肺癌导向疗法的初步观察  

STUDY ON THE GUIDED-DRUG- THERAPY OF HUMAN LUNG CANCER IMPLANTED ON NUDE MOUSE

作　　者：贾心善[1] 姜涛[1] 裴惠敏[1] 董文慧[2] 钱本余[2] 

机构地区：[1]中国医科大学病理解剖教研室 [2]吉林省药品检验所

出　　处：《中国医科大学学报》1989年第4期247-250,共4页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：本研究将CEA阳性肺腺癌细胞系移植于裸鼠,形成实体瘤,再经尾静脉投用我们制成的CEA抗体与丝裂霉素的复合体,观察导向治疗的效果。结果表明,CEA-MMC实验组与对照组治疗效果有非常显著的差异,经CEA-MMC治疗的CEA阳性肺癌中大片癌细胞坏死,炎性细胞浸润。本研究为今后的实验和临床应用提供了重要资料。The conjugation of mitomycin C-carcincombtyonic antigen antibody (MMC-CEAAb)was made, and an investigation was performed to observe antitumor activity of MMC-CEAAb in nude mouse, with CEA positive lung cancer by transplantation of CEA positive cancer cell line. The difference was significant in comparison with the control group. The results strongly indicated the MMC-CEAAb was concentrated on the tumor tissue. The suggestion was also supported by the radio activity of CEA-^(125) Ⅰ test.

关 键 词：肺癌 导向疗法 

分 类 号：R734.205[医药卫生—肿瘤]