胰液糖抗原19-9含量对胰腺癌的诊断意义  

The Diagnostic Significance of Carbohydrate Antigen 19-9 in Pancreatic Carcinomas

作　　者：陈元方[1] 麦灿荣 铁振军[2] 冯子坛[3] 陆星华 陆国钧 薛友华 潘国宗[1] 

机构地区：[1]协和医院 [2]北京宣武医院内科 [3]石家庄白求恩国际和平医院

出　　处：《中国医学科学院学报》1989年第3期229-231,共3页Acta Academiae Medicinae Sinicae

摘　　要：糖抗原19-9(CA 19-9)是从结肠癌细胞株SW 1116分离的抗原成分,其血清含量在许多消化道肿瘤均增高,因而被认为是一种胃肠道肿瘤相关抗原。本文探讨CA19-9在胰腺癌诊断中的意义。对象与方法CA19-9测定 用单克隆抗体固相免疫放射药盒,由美国CENTOCOR公司惠赠。研究对象 432名,其中正常人71名(本院工作人员、学生及献血员),良性消化系疾病116例(包括慢性胃炎、溃疡病、总胆管结石及慢性胰腺炎),胰腺癌44例,壶腹癌22例,胆管癌19例,胃癌98例,CA 19-9 is a carbohydrate antigen isolated from a human colon carcinoma cell line and reportedly related to gastrointestinal cancers and important for the diagnosis of pancreatic cancer. The present study was aimed rat evaluating the diagnostic significance of CA19-9 by determining serum and pancreatic juice CA 19-9 in 432 and 86 subjects, respectively, including pancreatic cancer patients, normal persons, and patients with a variety of benign and malignant gastrointestinal diseases. An increase of serum CA 19-9 was found in 73% of pancreatic cancer patients, 50% had levels higher than 120u/ml, and both of these were significantly higher than normal persons and patients with benign and other malignant diseases. CA 19-9 in the pancreatic juice of pancreatic cancer patients was significantly elevated, whereas in chronic pancreatitis patients it was entirely normal, indicating that CA 19-9 is a valuable tumor marker important for the differential diagnosis of pancreatic cancer.

关 键 词：胰液糖抗原 胰腺癌 B超 CT诊断 

分 类 号：R730.45[医药卫生—肿瘤]