中国人α珠蛋白基因3′HVR多态分布的研究  

Restriction Fragment Length Polymorphism of α-Globin 3'HVR Locus in Chinese Population

作　　者：鲁晓宣[1] 茅一萍[1] 张军[1] 李明发[1] 高翼之[1] 王世浚[1] 

机构地区：[1]南京铁道医学院生物学教研室,南京210009

出　　处：《遗传》1995年第3期13-15,共3页Hereditas（Beijing)

基　　金：江苏省计划生育委员会资助;铁道部科技司资助

摘　　要：本文以3’HVR为探针，对来自全国17省市的51名无血缘关系的健康人进行PvuⅡ限制性片段长度的多态分析，发现3’HVR在片段大小的变异范围及基因频率的分布上均有中国人的特点．结果表明，纯合子占15.7％，杂合子占84.3％，102个等位基因共有34个长度不同的等位片段，大小从2．0－70kb之间里连续分布，主要分布在2．0－25kb及4.0－6．0kb，频率分别为0．43和0．34．并与刘国仰、余裕炉等的资料进行综合比较，初步揭示了中国人群中3’HVR的多态特点．51 unrelated Chinese individuals from 17 different provinces and cities were typed for PvuⅡ restiction fragment length polymorphism with the probe 3'HVR. The frequencies of homozygotes and heterozygotes were estimated as 15.7% and 84.3%, 34 distinguishable allele sizes showed a continue distribution from 2.0-7.0 kb. The main alleles of 2.0-2.5kb and 4.0-6.0 kb gave the gene frequencies of 0.43 and 0.34 respcctive1y. The preliminary characteristics of 3'HVR locus in Chinese population were revealed.

关 键 词：RFLP 高变区序列 人类 α珠蛋白基因族 中国人 

分 类 号：Q987[生物学—遗传学]