沙棘油和维生素E对冷暴露大鼠脂质过氧化作用的影响  

EFFECT OF SEA BUCKTHRON OIL AND VITAMIN E oN LIPIDPEROXIDATION OF RAT AFTER COLD EXPOSURE

作　　者：宋志宏[1] 高应[1] 

机构地区：[1]蚌埠医学院临床生化教研室,山西医学院生化教研室

出　　处：《营养学报》1995年第1期27-31,共5页Acta Nutrimenta Sinica

摘　　要：大鼠低温暴露后血及肝脏组织中ＬＰＯ含量显著升高，ＧＳＨ一Ｐｘ和ＳＯＤ活性明显下降；透射电镜下观察，肝线粒体明显肿胀，嵴断裂，结构不清甚至消失，基质电子密度降低。饲料中加入一定量的ＶＥ或沙棘油均可使上述指标的变化明显改善，接近于室温下正常对照组水平。沙棘油的改善效果优于同等剂量的ＶＥ。表明：沙棘油和ＶＢ可通过其抗脂质过氧化作用，提高机体的耐寒力。he changes of lipid peroxides content(LPO),glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)activities in blood and liver of rats were determined after cold exposure with Sea Buckthron oil or vitamin E supplement into the feed, in order to observe their effects.LPO content markedly increased,but the activities of GSH-Px and SOD were significa- ntly decredtsed.TEM was empolyed to study the morphological changes of mitochondria。Sea Buckthron oil or vitamin E could make the above values close to levels of the control group。The effect of Sea Buckthron oil was better than that of vitamin E when doses were the same。Sea Buckthron oil and Vitamin E might enhance cold tolerance through anti一 lipid peroxi一 dation。

关 键 词：沙棘油 维生素E 冷暴露 过氧化脂质 

分 类 号：R977.25[医药卫生—药品] R965.2[医药卫生—药学]