大鼠脑缺血后各脑区多巴胺的动态变化  

Sequent changes of dopamine in different regions of rat brain after cerebral ischemia

作　　者：张志坚[1] 慕容慎行[1] 林新霖[1] 许国英[1] 吴秀丽 

机构地区：[1]福州福建医学院附属第一医院神经病学研究室,350005

出　　处：《中风与神经疾病杂志》1995年第2期71-72,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：采用大鼠4血管关闭全脑缺血方法动态观察48只大鼠脑的皮质、基底节、丘脑、以及脑干中的多巴胺(DA)在不同缺血时间的含量变化。结果显示大鼠脑缺血时存在脑DA的紊乱。随着缺血时间的延长(6h内),DA在脑干与皮质降低,在基底节与丘脑呈双向波动,且各脑区的含量变化不存在相关关系。这些发现提示脑缺血时各脑区的DA含量有着各自的变化。The Sequent changes of dopamine ( DA) in cortex, brain stem, basal ganglia and thalamus of 47 rats were observed with four -vessel occlusion method. The results showed that there was disorder of DA while rat brain was ischemia in which the levels of DA were decreased in cortex and brain stem,and waved in basal ganglia and thalamus,and there was no correlation to be found among these regions, these findings suggest that there were specialities concerning the DA distribution in different ischemic brain regions.

关 键 词：脑缺血 多巴胺 脑区 病理化学 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]