脑血管病患者血清及红细胞膜唾液酸含量研究  

The study of sialic acid concentration in plasma and an erythrocyte membranes of patients with cerebrorascular disease

作　　者：吴军[1] 王志群[1] 李珂静[1] 牛福忠 

机构地区：[1]佳木斯医学院第一附院

出　　处：《中风与神经疾病杂志》1995年第4期206-207,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：本文测定了３８例脑血管病患者和２６例正常人血清及红细胞膜ＳＡ含量。结果：脑血管病患者血清ＴＳＡ含量明显高于对照组（Ｐ＜０．０１），红细胞膜ＳＡ含量明显低于对照组（Ｐ＜０．０５），且出血量及梗塞灶大小与血清ＴＳＡ呈正相关（Ｐ＜０．０５），与红细胞膜ＳＡ含量呈负相关（Ｐ＜０．０１）。恢复期患者的血清ＴＳＡ显著低于急性期（Ｐ＜０．０５），其红细胞膜ＳＡ含量极显著高于急性期患者（Ｐ＜０．０１）。而脑出血与脑梗塞及其不同年龄，性别组间血清和红细胞膜ＳＡ含量均无显著性差异（Ｐ均＞０．０５）。提示脑血管病患者血清及红细胞膜ＳＡ含量变化，可以反映脑血管病患者脑损伤的程度，对指导治疗、判定预后具有一定的参考意义。In this article,both concentration of TSA in plasma and SA in erythrocyte membranes in 38 cases were measured. The result showed that the TSA concentration in plasma of cerebrovascular patients was higher than that of control group(P<0. 01 ) while the SA concentration was lower than control group (P<0. 05). The amount of bleeding and the infarct size showed positive correlation with TSA in plasma (r= 0.3295,P<0.05) but showed negative correlation with SA in erythrocyte membranes(r=-0.4298,P<0.01) were lower than that in acute stage (P<0. 05) but the SA in erythrocyte membranes were higher than that of acute stage patients (P<0.01 ). There were no difference for TSA in plasma and SA in erythrocyte of cerebral hemorrhage patients and cerebral infarction patients with different age and sex(P>0. 05).

关 键 词：脑出血 脑梗塞 唾液酸 红细胞膜 脑血管疾病 

分 类 号：R743[医药卫生—神经病学与精神病学]