地奥心血康对心肌缺血再灌犬血清肾上腺素含量，心脏指数及总外周血管阻力的影响  

Effect of Diaoxinxuekang on cardiac index,total peripheral vascular resistance and noradrenaline content in ischemia and reperfusion

作　　者：王蔚东[1] 赵丹[1] 吕文伟[1] 刘子红[1] 张键[1] 赵雪俭[1] 周正质[1] 刘中荣[1] 

机构地区：[1]白求恩医科大学病理生理教研室,中科院成都地奥制药公司

出　　处：《中国病理生理杂志》1995年第3期272-275,共4页Chinese Journal of Pathophysiology

摘　　要：杂种犬随机分为地奥心血康治疗组（ＤＫＧ）及生理盐水对照组（ＣＧ）。应用荧光法测定血清去甲肾上腺素（ＮＥ）含量，定时测定平均动脉压（ＭＢＰ），心输出量（ＣＯ），计算总外周血管阻力（ＴＰＶＲ），心脏指数（ＣＩ）。结果显示：（１）再灌后的ＭＢＰ在ＤＫＧ与ＣＧ之间无明显差异，Ｐ＞０．０５；（２）再灌２４０ｍｉｎ时，ＤＫＧ中ＣＩ值高于ＣＧ（Ｐ＜０．０１）；ＮＥ值与ＴＰＶＲ值明显低于ＣＧ（Ｐ＜０．０５，Ｐ＜０．０１）；（３）ＤＫＧ中ＮＥ与ＣＩ无相关性，ＣＧ中二者呈负相关，ｒ＝－０．６８３１，Ｐ＜０．０１；（４）两组ＣＩ与ＴＰＶＲ均呈负相关，ｒ＿（ＣＧ）＝－０．７７８３，Ｐ＜０．００１，ｒ＿（ＤＫＧ）＝－０．５２１８，Ｐ＜０．００１。Twenty hybrid dogs were randcmly divided into normal saline controlgroup ( CG)and myocardial ischemia/reperfusion Diaoxinxuekang treated group(DKG ).Noradrenaline(NE)content in serum was assayed by fluoresence,total peripheral resis-tance(TPVR) ,cardiac index(CI)were calculated by assaying mean blood pressure(MBP ) and cardiac cutput(CO).The results indicated:(1) No obvious differencein MBP could be found between DKG and CG after reperfusion(P>0.05).(2)After 240 min of reperfusion,CI in DKG is higher than that in CG. On the contraryNE and TPVR were much lower(P<0.05,P<0.01)while definite positive correla-tion was shown between NE and TPVR( P<0.01,r=0.442).(3 ) There was nocorrelation between NE and CI in DKG, and a negtive correlation was in CG respec-tively( r=-0.6831,P<0.01).(4)CI was inversely correlated with TPVR in bothgroups( P<0.01,r (CG)=-0.7783,r_(DKG)=-0.5248),These results suggested that Diao-xinxuekang increased cardiac output by strengthen myocardiac contract functiodirectly.

关 键 词：地奥心血康 心肌缺血 灌注法 肾上腺素 血管阻力 

分 类 号：R363.13[医药卫生—病理学] R965.1[医药卫生—基础医学]