亚硝酸钠对饲克山病病区粮大鼠血液流变学影响  

THE EFFECTS OF NaN02ON HEMORHEOLOGY INDEXES OF WISTAR RATS FED WITH GRAIN FROM KESHAN DISEASE AREA

作　　者：刘为民[1] 李广生[1] 孙波[1] 张秀云[1] 邹雅斌[1] 王凡[1] 肖淑芬[2] 马力[2] 孙淑艳[3] 

机构地区：[1]白求恩医科大学应用基础医学研究所 [2]白求恩医科大学一院核医学科 [3]白求恩医科大学一院检验科

出　　处：《中国地方病防治》1995年第6期330-332,共3页Chinese Journal of Control of Endemic Diseases

基　　金：国家"八五"攻关项目资助

摘　　要：以低硒(Se)低维生素E(VE)的克山病病区粮饲养大鼠10周,用腹腔注射亚硝酸钠引起急性缺氧的方法。结果表明,病区粮组大鼠红细胞变形性、GSH—Px、Cu、Zn—SOD活力降低,血清CK、LPO含量增高。补Se和VE可使上述变化逆转。结果提示,红细胞变形性、抗氧化能力和自由基代谢障碍,是亚硝酸钠与Se和VE缺乏协同造成心肌损害的作用环节。The reductions in the erythrocyte modification (ED) ,glutathione peroxidase and Cu,Zn-SOD activities accompanied with increases of creatine phosphokinase and lipid peroxides concentrations was observed in Wistar rats who are maintained on low selenium (Se) and vitamin E (VE)diets from Keshan Disease endemic area for 10 weeks and who have been injected NaNO2 for 3 days. The results show that ED,antioxidases and free radical metabolic disorder may take part in the mechanism of myocardial lesion caused by injected NaNO2 and diet deficiency of Se and VE.

关 键 词：红细胞变形性 亚硝酸钠 硒 维生素E 克山病 

分 类 号：R542.305[医药卫生—心血管疾病]