苯作业工人和白血病患者环核苷酸代谢的比较研究  

Study of Cyclic Nucleotide Metebolism in Benzene Operating Workers and Patients with Leukemia

作　　者：黄雪玉[1] 吕灿群[1] 唐世超[1] 

机构地区：[1]皖南医学院预防医学教研室,皖南医学院生物化学教研室,附属弋矶山医院血液科

出　　处：《中国公共卫生学报》1995年第2期75-77,共3页

摘　　要：采用放射性同位素法对苯作业工人、急性白血病患者、慢性白血病患者、消化性溃疡患者各１１例．正常对照组２２例进行了血浆坏磷酸腺苷（ｃＡＭＰ），环磷酸鸟苷（ｃＧＭＰ）水平和腺苷酸环化酶（ＡＣ）．环腺苷酸磷酸二酯酸（ＰＤＥ）比活力的检测．结果发现：苯作业工人和白血病患者血浆ｃＡＭＰ含量和Ｓｃ比活力较正常对照组明显降低（Ｐ＜０．０１）；苯作业工人的ＰＤＥ比活力较正常对照组高（Ｐ＜０．０５）．而白血病组的ＰＤＥ比活力与正常对照组比较差异无显著性（Ｐ＞０．０５）；苯作业工人和白血病患者ｃＧＭＰ含量均较正常对照组增高（Ｐ＜０．０１）；消化性溃疡患者血浆中ｃＡＭＰ、ｃＧＭＰ含量和ＡＣ、ＰＤＥ比活力与正常对照组差异均无显著性意义（Ｐ＞０．０５）。The plasma level of cyclic adenosine 3'5'-monophosphate(cAMP). specific activity of adenylate cyclase(AC) and phosphodiesterase(PDE)as well as level of cyelic guanosine 3'5'monorhosphate(cGMP) went measured with radioisotopic method in 11 benzene operating workers 22 patients with acute and chronic leukemia, 11 patients with digestive ulcer and 22 normal subjects. Research found that the plasma cAMP level and AC specific activity in benzene operating workers and patients with leukemia were significantly reduced than that in control (P<0.01). The PDE specific activity in benzene operating workers was higher than that in control. but the PDE specific activity in patients with leukemia was no significantly different than that in control(P> 0.05 ). The level of cGMP in benzene operating workers and patients with leukemia was significantly higher than that in control(P<0.01 ). The level of cAMP .cGMP and specific activity of AC and PDE in patients with digestive ulcer were no significantly,different than that in control(P>0.05 ). The mechanism of the benzene toxicology and ther egulating and significance of cychie nucleotide metabolism in benzene operating workers and patients with leukemia were discussed.

关 键 词：环核苷酸 苯 白血病 苯作业工人 代谢 

分 类 号：R733.702[医药卫生—肿瘤]