褐藻糖胶的免疫调节作用  

AN EXPERIMENTAL STUDY ON IMMUNOREGULATORY EFFECT OF FUCOIDAN

作　　者：杨晓林[1] 孙菊云[1] 许汉年[1] 刘晓慧[2] 张翼伸[2] 张绍伦[1] 

机构地区：[1]白求恩医科大学,长春130021 [2]东北师范大学生物系

出　　处：《中国海洋药物》1995年第3期9-13,共5页Chinese Journal of Marine Drugs

摘　　要：观察了从海带中提取的褐藻糖胶对小鼠免疫功能的影响。褐藻糖胶在体外可诱导白细胞介素—1(IL—1)和丙型干扰素(IFN—γ)产生;体内给药可增强T细胞、B细胞、巨噬细胞(M_φ)和自然杀伤细胞(NK细胞)功能,促进对绵羊红细胞(SRBC)的初次抗体应答。Funcoidan (FCD) is a polysaccharide extracted from Laminaria japonica Aresh. When we injected FCD into mice subcutaneously for 9 days in our experiments, splenocyte proliferation induced by mitogen (Con A, PHA, LPS), IL - 1 production of peritoneal M?induced by Lps and IL - 2 production of splenocyte induced by Con A were promoted and the primary antibody response to SRBC of murine splenocyte was also promoted. FCD could directly stimulated murine splenocyte to produce IFN - 7. FCD, in vitro or in vivo ,could enhance NK activity.

关 键 词：褐藻糖胶 免疫调节 

分 类 号：R977.6[医药卫生—药品]