鱼油中EPA和DHA对麻醉大鼠左室功能的影响  

EFFECT OF FISH OIL ON LEFT VENTRICULAR FUNCTION IN ANESTHETIZED RATS

作　　者：周建政[1] 吴葆杰[1] 张岫美[1] 

机构地区：[1]山东医科大学基础部药理学教研室

出　　处：《中国海洋药物》1995年第3期5-8,共4页Chinese Journal of Marine Drugs

摘　　要：观察了鱼油对麻醉大鼠基础左室功能和异丙肾上腺素(ISO)诱导的左室功能改变的影响。实验结果表明,鱼油(EPA和DHA,70％,1.4mL/kg)摄入2w对大鼠基础心功能无显著影响,但可显著地抑制ISO(10~6mol/L,10^(-5)mol/L,10(-4)mol/L)诱导的正性肌力和正性频率作用,对ISO诱导的心室前负荷的改变却无显著影响。结果提示,EPA和DHA的摄入可能影响大鼠心肌细胞膜上β-受体的功能。The effect of fish oil on the basal left ventricular function and changes of left ventricular function induced by isoprenaline (ISO) was demonstrated in the study. The determination of cardiac performance in vivo showed that supplementation with fish oil (EPA and DMA,70%, 1. 4 mL/kg) had no significant effect on basal cardiac performance,while it could significantly inhibit the gains of +dp/dtmax,Vpm and HR induced by ISCK10 6 mol/L, 10 3 mol/L, 10 4 mol/L) introvenously. The result suggest that supplementation with fish oil have some effects on the function of B-adrenoceptors on rat myocardial membrane.

关 键 词：鱼油 左室功能 二十碳五烯酸 麻醉 DHA 

分 类 号：R977.6[医药卫生—药品] R614[医药卫生—药学]