炔诺酮-α、β-聚(4-羟丁基)-DL-天冬酰胺高分子药物体外体内释放的研究  

Studies on The Polymeric Drug In-Vitro and In-Vivo Release of Norethindrone-α, β-Poly ( 4-Hydroxybutyl )-DL-Asparamide Conju-gates.

作　　者：汤谷平[1] 陈启琪[1] 单达先[1] 洪小珍 

机构地区：[1]浙江医科大学药学系分析化学,杭州310006

出　　处：《中国计划生育学杂志》1995年第2期80-81,119,共3页Chinese Journal of Family Planning

摘　　要：本实验对粒度相近载药量不同的炔诺酮-α、β聚(4-羟丁基)-DL-天冬酰胺(NET-PHBA)高分子药物进行体外释放研究。实验表明,释放量与载药量成正比,与药物颗粒大小成反比。同时,对NET-PHBA在兔体内释放作了初步探索。The in-vitro and in-vivo release of NET loading in α, β-poly ( 4-hydroxybutyl )-DL-asparamide conjugates ( NET-PHBA ) was studied. The experiment showed the NET loading had a effect on the rates of in-vitro release. It meant higher NET loading had a faster release. The result of different particle size which had same NET loading showed smaller particles had a faster release than that of larger ones. In order to study the in-vivo release of NET-PHBA,the polymeric drug (10. 9 mg-NET-PHBA per female rabbits , 4-rabbits per group ) was injected muscle of female rabbits weighting 2. 1-2. 5Kg. Column Switching HPLC method was used for determination the serum concentration of NET.

关 键 词：炔诺酮 聚丁二酰亚胺 体外释放 体内释放 避孕药 

分 类 号：R979.21[医药卫生—药品]