唾液CEA单克隆抗体检测诊断胃癌及癌前病变研究  

STUDY ON DIAGNOSIS OF GASTRIC CARCINOMA AND PRECAN-CEROUS LESIONS BY SALIVA CEA MONOCLONAL ANTIBODYTEST

作　　者：熊洪翔 凌基华 林金新[1] 陈凤岐[1] 

机构地区：[1]福建省中医药研究院,福建省莆田县医院

出　　处：《中国免疫学杂志》1995年第6期352-354,共3页Chinese Journal of Immunology

基　　金：福建省科委重点项目

摘　　要：探讨了唾液ＣＥＡ检测对诊断胃癌及癌前病变的意义，８４６例健康人唾液ＣＥＡ均值为３５．５０±１６．３５ｎｇ／ｍｌ。３５０例有症状者唾液（颜色、粘稠度、气味有不同改变）ＣＥＡ含量与疾病有关。７０９例胃癌高发区不同地区分别为４６．０７±１７．３３、６７．５０±２５．６５、１０４．５０±３９．７７ｎｇ／ｍｌ。对启发区５８例ｃＥＡ阳性者作胃镜及活检，确诊４例早期胃癌，１例晚期胃癌，４７例癌前病变，占总数９０％。唾采取材方便，无创伤，可大批量进行，利于正常人发现胃癌及癌前病变者。此法可作为普查粗筛指标。To investigate the value on diagnosis of gastric carcinoma(GC)and precancerous lesions(PL)bv saliva CEA determination saliva CEA level was detected by monoclonoen-zymoimmunologic method in the person of high risk area of GC. It was found the CEA level wassignificantly elevated,and 90%of partiol CEA positive person was diagnosed as early and latestages of GC and PL by the gastroscope and biopsy.Since it is very easy and nontraumatic toget the saliva specimen,this test can be used as a marker of preliminary screening in the generalinvestigation and is advantageous to find the patients of GC and PL earlier as well.

关 键 词：唾液 癌前病变 胃肿瘤 单克隆抗体 诊断 

分 类 号：R735.204[医药卫生—肿瘤] R730.45[医药卫生—临床医学]