尿溶菌酶测定对镉毒性肾损害早期检测的价值  

Role for Urinary Lysozyme in Early Detecting Cd-induced Renal Damage

作　　者：王翔朴[1] 郭卫星[1] 陈本美[1] 周晓娟[1] 林鸿恩 肖永定 谭昌荣 

机构地区：[1]湖南医科大学环境医学研究室 [2]水口山矿务局职工医院

出　　处：《中华劳动卫生职业病杂志》1989年第1期12-14,18,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：中国科学院自然科学基金

摘　　要：本文对149例镉作业工人进行了尿溶菌酶、β_2-MG、蛋白质总量及尿镉含量测定,发现尿镉是反映体内镉负荷的重要指标,但与镉损害、包括肾损害的程度无显著性相关.尿β_(?)-MG 及(?)菌酶异常升高是镉毒性肾损害早期的表现较蛋白质总量敏(?)。特异。β_2-MG 与溶菌酶呈显著正相关,而且尿溶菌酶与其他肾损害指标的符合率似较β_(?)-MG 更高。故尿溶菌酶升高对镉中毒性肾损害的检测具有重要价值。Lysozyme,β_2-microglobulin,total protein and Cadmiumcontent in urine were measured in 149 Cd-exposed workers.Re-sults support that urinary Cd content could be served as an us-eful indicator for Cadmium body burden,but there is no signi-ficant correlation with other Cd poisoning indicators,includingrenal damage.Abnormal increase of urinary β_2-microglobulinand lysozyme is the early phenomena of Cd-induced renal da-mage,It seems more sensitive and more specific than urinary to-tal Protein.Urinary lysozyme is significantly correlated withurinary β_2-microglobulin.Its conformability with other renaldamage indicators also seems better than that of urinary β_2-micr-oglobulin.It is obvious that increasing of urinary lysozyme isa valuable indicator for early detecting of Cd-induced renal damage.

关 键 词：溶菌酶测定 镉 肾损害 早期检测 

分 类 号：R598.104[医药卫生—内科学]