SLE患者尿中补体抑制活性的研究  

A STUDY ON THE URINARY COMPLEMENT INHIBrrORY AC-TIVITY OF SLE PATIENTS

作　　者：姚建[1] 黎磊石[1] 胡伟新[1] 沈克勤[1] 

机构地区：[1]南京金陵医院

出　　处：《中国免疫学杂志》1995年第3期179-181,共3页Chinese Journal of Immunology

摘　　要：在建立尿中补体抑制活性的检测方法的基础上，研究了ＳＬＥ患者尿中的补体抑制活性，结果发现活动性ＳＬＥ患者尿中补体抑制活性较正常人及非活动性ＳＬＥ患者明显增加。这种抑制活性具有部分耐热性，并与尿中红细胞计数及尿蛋白浓度间无明显平行关系。我们的研究结果表明ＳＬＥ患者尿中具有高水平的补体抑制活性，这一研究可能有助于加深对ＳＬＥ病理生理的认识，检测尿中补体抑制活性可能具有临床诊断价值。he detecting system for urinary complement inhibitory activity was eatablished and used inthe study of the urinary complement regulatory activity of SLE patients. A signficant incrcasedcompiement inhibitory activity was found in the urines from SLE patients as compared withthose from normal control and resting SLE. The activity was partially resistant to heat treatment(56℃ , 30min)and did not paralled with the urinary red blcod cell counting and protein concen-trations. This study might be helpful in deepening our understanding of pathogenesis of SLE,and the detection of urinary complement regulatory activity could have diagnostic values.

关 键 词：SLE 红斑狼疮 补体调节蛋白 尿液 补体 抑制活性 

分 类 号：R593.241[医药卫生—内科学] R593.240.3[医药卫生—临床医学]