药物输注装置作肝癌局部化疗的并发症  

COMPLICATIONS OF REGIONAL CHEMOTHERAPY USINGDRUG DELIVERY SYSTEM FOR LIVER CANCER

作　　者：张晓华[1] 王义[1] 侯凯生 魏新豪 

机构地区：[1]上海第二军医大学长海医院肝胆外科研究所,空军上海第一医院外一科

出　　处：《中国普通外科杂志》1995年第2期69-73,共5页China Journal of General Surgery

摘　　要：本文总结６６例肝癌使用药物输注装置作肝动脉或门静脉灌注化疗过程中发生的毒副反应和并发症。毒副反应包括白细胞减少占４８．５％，血小板减少占３７．９％，恶心、呕吐、纳差占４３．９％。并发症有２９例，发生率４３．９％，内有急性胃十二指肠粘膜病变１０例（１５．２％）、导管堵塞５例（７．５％）、药液外漏４例（６．１％）、药囊周围积血、积液４例、药囊感染３例（４．５％）和导管移位、急性胰腺炎、肝动脉闭塞各１例。作者讨论了药物输注装置常见并发症及其发生原因，并提出预防措施。AbstractSixty-six patients with liver cancer receiving hepatic artery or portal vein infusionchemotherapy using drug delivery system (DDS) are repotted. Toxicities of drugs were leu-copenia in 48. 5% of patients , thrombocytopenia in 37. 9% , nausea , vomiting and dyspepsiain 43. 9%. There were 29 (43. 9%) complications of DDS including acute gastro-duodenalmucosal lesion in 10 patients (15. 2%) , catheter obstruction in 5 (7. 5%) i , extravasation ofdrug in 4 (6- 1%), periportal accumulation of blood and fluid in 4, reservoir infection in 3(4- 5 % ) , catheter displacement in 1, acute pancreatitis in 1, and hepatic artery occlusion in1. The common complications of DDS, their causes and preventive measures are discussed.

关 键 词：肝癌 药物输注装置 并发症 药物疗法 

分 类 号：R735.705[医药卫生—肿瘤]