人血丙种球蛋白制备的新工艺  

A New Production Technology of Human Immunoglobulin G

作　　者：刘鹏输 何承举[1] 潘越飞[1] 黎新[1] 卢平[1] 

机构地区：[1]广西血液中心,柳州545005

出　　处：《中国生化药物杂志》1995年第2期72-75,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：本文报道了利凡诺-低温乙醇-DEAE离子交换层析结合法制备人血丙种球蛋白的新工艺,按此工艺,IgG收率约0.5％（g/ml）,纯度>99％,制剂各项指标均符合规程要求。以VSV为病毒模型,制备过程至少可失活或排除10^(11)ID_(50)/ml病毒,工艺对灭活脂质壳病毒是有效的。A new human Immunoglobulin G production technology by Rivanol-cold ethaonl-DEAE ion-exchange chromatography was reported in this paper. According to this technological process, IgG recovery was 0. 5% (g/ml) or so, and purity> 99%. All quality index of IgG preparation could meet the clinical requirement. The technological process could inactived or removed 1013lD50/ml VSV at least.

关 键 词：人血丙种球蛋白 制备 工艺 生物制品 

分 类 号：R392－33[医药卫生—免疫学] TQ464.56[医药卫生—基础医学]