有机溶剂/表面活性剂灭活凝血因子制剂中病毒的验证  

Verification of Inactivation Efficiency of Virus in Coagulation Factors by Solvent/Detergent Method

作　　者：吕林红 刘世维 黄浩[1] 郭亮[1] 王锐丽 宋丽亚 倪道明[1] 

机构地区：[1]卫生部北京生物制品研究所,北京100024

出　　处：《中国生物制品学杂志》1995年第3期105-106,118,共3页Chinese Journal of Biologicals

摘　　要：应用Horowitz’s有机溶剂／表面活性剂（S／D）对血液制品中病毒进行灭活。在三种凝血因子制剂（抗血友病因子Ⅷ，凝血酶原复合物，纤维蛋白原）中加入两种指示病毒（HSV－1和乙脑病毒）。结果证明S／D法对于易变性的血液衍生物中脂包膜病毒的灭活非常有效并且可行。HSV-1 and Japanese encephalitis virus using as indicators were added inblood coagulation factors (antihemophilic factorⅧ, prothrombin and fibrinogen) and inactivat-ed by Horowitz's solvent/detergent (S/D) method. The result proved that S/D method wassignificantly effective and feasible in the inactivation of lipid-enveloped viruses in labile plas-ma piotein derivatives.

关 键 词：凝血因子制剂 血液制品 病毒灭活 S/D法 

分 类 号：R392－33[医药卫生—免疫学] R457.1[医药卫生—基础医学]