未能切除的胰腺癌行区域性导向化疗临床应用报告  

Guided regional chemotherapy in unresectable pancreatic car-cinomas.

作　　者：郑扶民 陈英忠[1,2,3] 

机构地区：[1]第三临床学院 [2]白求恩医科大学基本外科 [3]中日联谊医院

出　　处：《中国实用外科杂志》1995年第4期213-215,共3页Chinese Journal of Practical Surgery

摘　　要：自１９８９～１９９２年间，作者共收治胰腺癌１９０例，其中有１５９例（８２．６％）未能切除，对其中３０例采用了区域性导向化疗，即在手术中经胃网膜右动脉逆行置管至胃十二指肠动脉，术后经该导管注入５－ＦＵ等化疗药物，一般每日２５０ｍｇ，共达１～２个月。根据随诊的１０８例接手术方式分为Ａ组单纯探查２４例，Ｂ组单纯胆肠转流５４例，Ｃ组单纯探查加区域性化疗１８例，Ｄ组胆肠转流加区域性化疗１２例。中位期分别为Ａ组３．５个月，Ｂ组５．５个月，Ｃ组７．５个月，Ｄ组９．７个月。四组比较各组间有非常显著差异（Ｐ＜０．０１），证明本疗法对未能切除的胰腺癌具有减轻症状，延长生存期的疗效。rom 1989 to 1992, 190 cases of pancreatic carcinoma havebeen treated in our department, 159 (82. 6% )cases were unresectable, and 30 cases of them were treated with guided regional chemotherapy which consisted of per-operative insertion of catheter into gastroduodenal artery through right gastroepiploic artery and postoperative administration of 5-FU(250￣500mg/d)for 1 ￣ 2 months. In 108 followed up cases,four groups have been divided for compalison. Group A consisted of 24 simple laparotomy cases with a median survivaltime (MST)of 3. 5 months IGroup B, 54 cases of bilio-enterostomy with MST of 5. 5 mos ;Group C, 18 cases of laparotomyplus regional chemotherapy with MST of 7. 5 mos;GroupD,12 cases of bilio--enterostomy plus regional chemotherapywith MST of 9. 7 mos. There were very significant differencsamong the four groups (P<0.01).We suggested that regionalchemotherapy provid the effects in patients with relievingsymptoms and prolonging survival time in patients with unresectable pancreatic carcinoma.

关 键 词：胰腺肿瘤 区域性 药物疗法 癌 临床应用 

分 类 号：R735.905[医药卫生—肿瘤]