白三烯拮抗剂ONO-1078对电刺激迷走神经、辣椒素和P物质引起的豚鼠心血管反应的作用(英文)  

Effects of ONO-1078,a leukotriene antagonist,on cardiovascular responses induced by vagal stimulation, capsaicin. and substance P in guinea pigs

作　　者：魏尔清[1] 辛小华[1] 王瑶尘[1] 陈丽萍[1] 张丽芬[1] 卞如濂[1] 

机构地区：[1]浙江医科大学药理学教研室

出　　处：《中国药理学报》1995年第6期485-488,共4页Acta Pharmacologica Sinica

基　　金：Natural Science Foundation of Zhejiang Province, №391033.

摘　　要：阐明ONO-1078(ONO,4-氧-8-[对-(4-苯丁氧基)苯甲酰氨基]-2-(5-四唑基)-4H-1-苯并毗喃)对神经原性刺激诱导心血管反应的作用.方法:观察豚鼠心房和心室伊文思蓝渗出以及平均主动脉压(MAP)变化.结果:在阿托品(1 mg·kg^(-1),iv)预先处理后,电刺激迷走神经(ESV,10 Hz,5 ms,2或10 V,90 s)显著增高伊文思蓝渗出;辣椒素和P物质也增加染料渗出并降低平均动脉压(MAP).ONO(0.03,0.1 mg·kg^(-1),iv)抑制ESV的反应,在刺激强度低(2 V)时更明显;ONO 0.03 mg·kg^(-1)减弱辣椒素引起的微血管渗漏和低血压,但对P物质无影响.结论:ONO-1078可能通过抑制感觉神经肽释放而调节神经原性炎症时的心血管反应.To determine the role of ONO-1078, 4-oxo-8-[p-( 4-phenylbutyloxy) benzoyl-amino]- 2-( tetrazol-5-yl )-4H-1-benzopyran hemihydrate, in cardiovascular responses induced by vagal stimulation, capsaicin, and substance P. METHODS: Evans blue extravasation in the atrium and ventricle, and mean arterial pressure (MAP) were observed. RESULTS: Electric stimulation of vagus (ESV.10 Hz, 5 ms, 2 or 10 V, for 90 s) increased Evans blue extravasation in the hearts of atropine (1 mg·kg-1, iv)-pretreated guinea pigs. Capsaicin (0. 05 mg·kg-1, iv) and substance P (1μg·kg-1, iv) enhanced the dye extravasation and elicited a drop in MAP. ONO-1078 (0. 03 and 0.1 mg·kg-1, iv) inhibited ESV-induced response, especially at stimulation of 2 V. ONO-1078 (0. 03 mg·kg-1) attenuated capsaicin-induced cardiac microvas-cular leakage and hypotensive response, but failed to inhibit substance P-induced responses. CONCLUSION: ONO-1078 can modulate the cardiovascular responses in neu-rogenic inflammation, possibly mediated by inhibiting sensory neuropeptide release.

关 键 词：ONO-1078 苯并吡喃类 心脏 辣椒素 P物质 

分 类 号：R965.2[医药卫生—药理学]