得自小根蒜及薤中的几种含氮化合物  

Nitrogen-containing Compounds from Allium macrostmon Bunge.and Allium chinense G.Don

作　　者：彭军鹏[1] 乔艳秋[1] 姚新生[1] 

机构地区：[1]军事医学科学院放射医学研究所,沈阳药科大学植物化学教研室

出　　处：《中国药物化学杂志》1995年第2期134-139,共6页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金

摘　　要：从中药薤白的主要基源植物小根蒜（ＡｌｌｉｕｍｍａｃｒｏｓｔｅｍｏｎＢｕｎｇｅ）鳞茎中首次分得５种化合物。它们是腺苷（Ａｄｅｎｏｓｉｎｅ，１）、胸苷（Ｔｈｙｍｉｄｉｎｅ，２）、２，３，４，９－四氢－１－甲基－１Ｈ－吡啶骈［３，４－ｂ］吲哚－３－羧酸（２，３，４，９－ｔｅｔｒａｈｙｄｒｏ－１－ｍｅｔｈｙｌ－１Ｈ－ｐｙｒｉｄｏ［３，４－ｂ］ｉｎｄｏｌｅ－３－ｃａｒｂｏｘｙｌｉｃａｃｉｄ，３）、２，３，４，９－四氢－１Ｈ－吡啶骈［３，４－ｂ］吲哚－３－羧酸（２，３，４，９－ｔｅｔｒａｈｙｄｒｏ－１Ｈ－ｐｙｒｉｄｏ［３，４－ｂ］ｉｎｄｏｌｅ－３－ｃａｒｂｏｘｙｌｉｃａｃｉｄ，４）和丁香甙（Ｓｙｒｉｎｇｉｎ，５）．从另一种基源植物薤（Ａ．ｃｈｉｎｅｎｓｅＧ．Ｄｏｎ）鳞茎中分得腺苷（１）、色氨酸（Ｔｒｙｐｔｏｐｈａｎ，６）和化合物（４）．Bulbs of both Allium macrostemon Bunge.and Allium chinense G. Don are main souces of the traditional Chinese medicinal herb 'Xiebai'.five compounds were isolated from the former species which were identified as adenosine(1).thymidine(2).2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-3-carboxylic acid(3),2,3,4 ,9-tetrahydro-1H-pyrido[3,4b]indole-3-carboxylic acid(4)and syringin (5).(1～4)are nitrogen-containing compounds.(1)and(4)were also separated from the latter plant along with tryptophan(6).Both(1)and(4)showed strong inhibitory activity on human platelet aggregation in vitro.

关 键 词：小根蒜 薤 含氮化合物 分析 提取 中药化学 

分 类 号：R284[医药卫生—中药学]