高氟区青少年血清25－羟维生素D水平对骨龄延迟的影响  

An Analysis of the Changes in Serum 25-Hydroxyvitamin D in Adolescents with Skeletal Age Retardation in High-Fluoride Arta

作　　者：冯洪刚[1] 齐今吾[1] 戴国钧[1] 张志瑜[1] 钱聪[1] 李晶[1] 刘东风[1] 张希达 马春林 成金山 高洪信 魏景阳 苏广民 王明辉 

机构地区：[1]中国医科大学第一临床学院内分泌学教研室,中国医科大学预防医学系流行病学教研室,中国医科大学第二临床学院放射线科,赤峰市卫生防疫站,敖汉旗卫生防疫站

出　　处：《中国医科大学学报》1995年第1期33-35,共3页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：本文调查了６１名高氟区和４８名非高氟区７～１８岁青少年的骨龄，并测定了骨龄正常组和延迟组血清２５－羟维生素Ｄ（２５－ＯＨＤ）及血清钙、磷水平。结果发现，高氟区青少年骨龄延迟率显著高于非高氟区；高氟区骨龄延迟组的血清２５－ＯＨＤ水平显著低于该地骨龄正常组；高氟区２５－ＯＨＤ的水平低于非高氟区。提示，高氟区青少年骨龄延迟与血清２５－ＯＨＤ水平低有关。e conducted a cross-sectional study of serum 25-hydroxymitamin D(25-OH D) level in 61 adoles-cents aged 7 18 yr,in an area of endemic fluorosis at a village in Inner-mongolia,while 48 adolescentsin a normal area nearby were also investigated.All adolescents were divided into two groups:skeletalage retardation group and normal skeletal group.The concentrations of serum fluoride, calcium andphosphorus were measured.The results showed that the levels of serum 25-OH D in the former groupwere significantly lower than that in the later in both areas(P<0.05).The levels of serum 25-OH Dand calcium in adolescents living in high-fluoride area showed markedly lower than that in normal area(P<0. 05,P<0.01).In normal skeletal age group,the serum calcium level in high fluoride area( P<0. 01).There was no statistic difference in serum calcium level between skeletal retardation groups inthese two areas. No difference was found in serum phosphorus levels between these two areas andgroups. No correlation was observed between levels of serum fluoride ,calcium and 25-OH D in both ar-eas. These results suggested that bone growth and development was delayed and the lower level ofserum 25-OH D might be related to the skeletal age retardation in adolescents living high-fluoride area.It is still unclear how high fluoeied intake influences the metabolism of vitamin D in adolescents.

关 键 词：地方病 25-羟维生素D 骨龄延迟 高氟区 青少年 

分 类 号：R599.901[医药卫生—内科学]