血清脂连唾液酸检测对卵巢癌病情监测的作用  

Serum Lipid-associated Sialic Acid(LSA)in Diagnosing and Monitoring Ovarian Cancer

作　　者：乐可赞[1] 卞美璐[1] 朱丹[1] 刘文淑[1] 许秀英[1] 连利娟[1] 

机构地区：[1]中国医学科学院,中国协和医科大学,协和医院

出　　处：《中国医学科学院学报》1995年第2期128-132,共5页Acta Academiae Medicinae Sinicae

摘　　要：对１６１例卵巢癌患者、２８例良性妇科疾病患者和２２例健康女性进行了血清肿瘤标志物脂连唾液酸（ＬＳＡ）测定，并与ＣＡ_（１２５）进行了对比。结果显示：ＬＳＡ与ＣＡ１２５在卵巢癌术前患者中敏感性分别为８３．０％和９２．５％，术后复发患者中阳性率分别达７３．７％和８２．５％；二者同时检测若只一种方法结果阳性就列为阳性，则其术后复发患者总阳性率可达８９．５％，ＬＳＡ与ＣＡ１２５对术后患者的阳性预测值分别为８９．４％和１００％，与术后病程符合率分别为９４．４％和１００％。因此ＬＳＡ检测法对诊断和监测卵巢癌与ＣＡ１２５效果接近，而且方法简单，价格低廉，不需同位素，有优于ＣＡ_（１２５）之处，便于临床应用。在不易获取ＣＡ_（１２５）检测药盒时检测血清ＬＳＡ也是一个比较可靠的监测指标。Serum from 161 patients with ovarian cancer,28 patients with benign gynecologic disorders and 22 healthy women,was assayed for levels of tumor marker LSA,which were compared with CA125.The results showed that in the patients with ovarian cancer,the sensitivities of LSA and CA125 for the patients prior to surgery were 83.0%and 92.5%,respectively;the sensitivities for the recurrent patients after surgery were 73.7%and 82.5%respectively.A total sensitivity of 89.5%was obtained by combination of both markers.The positive predictive value of LSA and CA125 for the patients with suspected tumor recurrence were 89.4%and 100%,respectively,and their corroborative rate with the postoperative courses were 94.4%and 100%,respectively.Thus serum assay of LSA,can be used in monitoring patients with ovarian cancer.The technique for determination of serum level of LSA is muchmore simple and less expensive than the radioimmuno-assay of serum level of CA125.

关 键 词：唾液酸 肿瘤标志物 卵巢肿瘤 

分 类 号：R737.310.4[医药卫生—肿瘤]