肝硬化与肝源性溃疡及幽门螺杆菌感染的临床研究  

Clinical Study between Liver Cirrhosis and both Hepatogenic Ulcer and Helicobacter Pylori Infection

作　　者：龙会宝[1] 陈玉成[1] 王连源[2] 

机构地区：[1]中山大学附属第二医院急诊科,510120 [2]中山大学附属第二医院消化内科,510120

出　　处：《岭南急诊医学杂志》2009年第6期445-446,449,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨肝硬化与肝源性溃疡及幽门螺杆菌(HP)感染的关系。方法:对我院近10年来符合标准的200例行胃镜检查的肝硬化患者(肝硬化组)及67例慢性肝炎患者(慢性肝炎组)的临床资料进行回顾性分析。结果:肝硬化组的溃疡发病率(32.0%,64/200)高于慢性肝炎组(22.4%,15/67),但差异无统计学意义(P>0.05)。肝硬化组中,溃疡发病率在肝功能A、B、C级分别为19.5%(15/77)、36.5%(31/85)和47.4%(18/38),A级与B级、A级与C级相比差异均有统计学意义,P<0.05。有溃疡者的HP阳性率40.6%(25/64)明显高于无溃疡者的16.9%(24/136),P<0.05。无、轻、中、重度门脉高压性胃病者溃疡发病率分别为23.4%(25/107)、30.0%(18/60)、60.0%(12/20)和69.2%(9/13);有、无门脉高压性胃病者溃疡的发病率相比有显著性差异。结论:肝硬化患者的肝源性溃疡发病率高于慢性肝炎患者,肝功能分级越差,溃疡发病率越高。肝源性溃疡的发生与HP感染及门脉高压性胃病有明显相关。Objective:To investigate the relationship between the cirrhosis and both hepatogenic ulcer and Helicobacter Pylori (HP)infection. Methods:A retrospective analysis was performed in 200 patients with liver cirrhosis examined by gastroscopy and 67 patients with chronic hepatitis in the Second Affiliated Hospital of Sun Yat-sen University in the past ten years. Results:The morbidity of hepatogenic ulcer in patients with liver cirrhosis (32.0%, 64/200)was higher than that of the patients with chronic hepatitis (22.4%, 15/67),but there was no statistical difference. The incidence rate of hepatogenic ulcer was 19.5% (5/77) in patients with Child's A, 36.5% (31/85) in Child's B, 47.4% (8/38) in Child's C. There was significant difference between Child's A and Child's B, and between Child's A and Child's C. The positive rate of HP in hepatogenic ulcer patients with cirrhosis was 40.6% (25/64).In cirrhotic patients without hepatogenic ulcer, HP positive rate was 16.9% (24/136). There was significant difference between the two groups. The morbidity of hepatogenic ulcer was 30.0% (18/60) in patients with light PHG, 60.0% (12/20) in those with moderate PHG, 69.2% (9/13) in those with heavy PHG, and 23.4% (25/ 107) in those without PHG. There was significant difference in the morbidity of hepatogenic ulcer between the patients with PHG and those without PHG. Conclusion: The morbidity of hepatogenic ulcer in patients with liver cirrhosis is higher than that of the patients with chronic hepatitis. The incidence rate increases as liver function becomes worse. There was significant relationship between the occurrence of HU and both HP infection and PHG.

关 键 词：肝硬化患者 肝源性溃疡 幽门螺杆菌感染 临床研究 HELICOBACTER PYLORI Infection Liver Cirrhosis 门脉高压性胃病 发病率 慢性肝炎 统计学意义 肝炎患者 肝功能分级 显著性差异 回顾性分析 胃镜检查 临床资料 阳性率 重度 结果 关系 

分 类 号：R575.2[医药卫生—消化系统] R573.1[医药卫生—内科学]