河南省贲门癌高、低发区幽门螺杆菌感染与贲门癌变的关系  

Infection of Helicobacter pylori in gastric - cardia cancerous lesions:a comparative study between the high - and - low risk populations

作　　者：黄静[1] 王苒[1] 李吉林 岳文斌 艾永红[1] 范宗民[1] 王立东[1] 

机构地区：[1]河南省食管癌重点开放实验室,郑州450052 [2]河南省林州市姚村食管癌医院病理科 [3]河南省濮阳市第一人民医院肿瘤内科

出　　处：《中国实用医刊》2010年第7期1-2,共3页Chinese Journal of Practical Medicine

基　　金：国家杰出青年科学基金(30025016);国家自然科学基金〔30670956〕;河南省医学科技攻关基金(20058) ;河南省高等学校杰出科研人才创新工程基金(1999125)

摘　　要：目的 探讨贲门癌高、低发区幽门螺杆菌(Hp)感染与贲门癌变的关系.方法 于贲门癌高、低发区分别选择262例贲门癌患者取外周全血,利用胃Hp检测试条检测Hp感染情况并进行分析.结果 贲门癌高、低发区贲门癌患者Hp感染率分别为49%、48%.高、低发区贲门癌患者Hp感染率男女分别为64%、36%和92%、8%,两者比较差异均有统计学意义(P均＜0.05),高、低发区贲门癌患者Hp感染率随年龄增长均明显增高(P＜0.05),50～70岁为发病高峰年龄;高发区贲门癌家族史阳性患者Hp感染率明显高于低发区贲门癌家族史阳性患者,低发区贲门癌家族史阳性患者Hp感染率明显低于贲门癌家族史阴性患者Hp感染率(P＜0.05).结论 Hp感染可能与贲门癌的发生、发展有一定关系,Hp感染率高的人群贲门癌易感性较低.Objective To further elucidate the possible relationship between infection of Helicobacter pylori(Hp)and gastric cardia carcinogenesis on the subjects from HIA and LIA for GCC.Methods Helicobacter pylori Kit were undertaken to determine the expression of Hp in gastric cardia carcinogenesis.Two hundred and sixty -two surgical resected GCA specimens were selected randomly from the hospital(161 from the HIA, 101 from the LIA).Results The ratio of Hp infection of the gastric - cardia adenocarcinoma was 49% and 48% in high and low - incidence areas for gastric cardia carcinogenesis (P ＞ 0.05).However, in high and low - incidence area, the rate of Hp infectiion of GCA in male was higher than in females and the older was higher than the young.The ratio of Hp infection of FH(+)in high - incidence area was apparently higher than that in the low - incidence area.However, in the LIA,the rate of Hp infection of FH(+)was apparently higher than the Hp infection of FH(-), P ＜ 0.05.Conclusions The affectability of GCA of Hp infection is low.Hp infection is correlated with the carcinogenesis and development of cardiac cancer in high and low - incidence area.

关 键 词：贲门癌 高、低发区 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]